INT31925

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Context Info
Confidence 0.43
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 7.59
Pain Relevance 2.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Agtr2) plasma membrane (Agtr2) transcription factor binding (Agtr2)
signal transducer activity (Agtr2)
Anatomy Link Frequency
superior 1
nerve 1
brain 1
lung 1
Agtr2 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 23 100.00 Very High Very High Very High
cOX1 1 100.00 Very High Very High Very High
COX2 1 100.00 Very High Very High Very High
Pain 4 99.62 Very High Very High Very High
Antinociceptive 8 98.96 Very High Very High Very High
Inflammation 79 98.36 Very High Very High Very High
noradrenaline 1 98.20 Very High Very High Very High
bradykinin 1 97.92 Very High Very High Very High
anesthesia 5 90.08 High High
isoflurane 4 89.64 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 7 99.96 Very High Very High Very High
Hypertension 57 99.64 Very High Very High Very High
Pain 3 99.62 Very High Very High Very High
Pressure Volume 2 Under Development 2 98.90 Very High Very High Very High
INFLAMMATION 78 98.36 Very High Very High Very High
Heart Rate Under Development 18 98.16 Very High Very High Very High
Left Ventricular Dysfunction 1 96.72 Very High Very High Very High
Cancer 91 93.24 High High
Stroke 4 93.00 High High
Diabetes Mellitus 84 92.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that, as in humans, mice exhibit hypotension in early pregnancy, and a blunted pressor response to angiotensin II, a decrease in hematocrit, and a marked increase in cardiac output in late pregnancy.
Negative_regulation (decrease) of angiotensin II associated with pressure volume 2 under development
1) Confidence 0.43 Published 2002 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 11834487 Disease Relevance 0.29 Pain Relevance 0.13
We found in awake ICR (CD-1) mice at 17.5 days gestation that hematocrit was reduced 18%, and the pressor response to intravenous angiotensin II was reduced ~33%.
Negative_regulation (reduced) of angiotensin II
2) Confidence 0.42 Published 2002 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 11834487 Disease Relevance 0.19 Pain Relevance 0.11
In the group repeatedly treated with losartan, ex vivo autoradiography depicted the marked decrease in angiotensin II-binding capacity to the sites containing exclusively AT1 receptors within the blood-brain barrier.
Negative_regulation (decrease) of angiotensin II in brain
3) Confidence 0.41 Published 1996 Journal Life Sci. Section Abstract Doc Link 8937511 Disease Relevance 0.07 Pain Relevance 0.31
Our previous studies revealed that chemical carcinogen-induced tumorigenesis in mouse colon [22] and lung [15] was significantly attenuated by AT2 receptor deficiency.
Negative_regulation (deficiency) of AT2 receptor in lung
4) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.58 Pain Relevance 0.04
Inhibition of angiotensin II activity enhanced the antitumor effect of cyclooxygenase-2 inhibitors via insulin-like growth factor I receptor pathway.
Negative_regulation (Inhibition) of angiotensin II associated with cox1
5) Confidence 0.29 Published 2003 Journal Cancer Res. Section Title Doc Link 14583467 Disease Relevance 0.48 Pain Relevance 0.25
In contrast, the antinociceptive effects of CP 55,940 in all pain models were fully retained in CB2 receptor knockout mice, along with the associated motor deficits.
Negative_regulation (retained) of CB2 receptor associated with targeted disruption, pain and antinociceptive
6) Confidence 0.09 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19538975 Disease Relevance 0.89 Pain Relevance 1.12
to block the angiotensin II receptor.
Negative_regulation (block) of angiotensin II receptor
7) Confidence 0.08 Published 2007 Journal PPAR Research Section Body Doc Link PMC1783742 Disease Relevance 0.90 Pain Relevance 0.03
There is evidence that drugs that selectively block angiotensin II receptors or ACE may have superior anti-inflammatory properties than other antihypertensive agents.
Negative_regulation (block) of angiotensin II in superior associated with inflammation
8) Confidence 0.08 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350124 Disease Relevance 1.19 Pain Relevance 0.26
Application with the proteasome inhibitor MG132 or lactacystin, but not the lysosome inhibitor E64, led to significant (P < 0.05) suppression of angiotensin II–induced degradation of synaptophysin (Fig. 4H and I).
Negative_regulation (suppression) of angiotensin II
9) Confidence 0.06 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.18 Pain Relevance 0
Indeed, we have previously shown that sEH inhibition reduces angiotensin II-induced hypertension [7], neo-intima formation in hyperlipidemic mice [8] and vascular remodelling in the monocrotaline-model in rats [9].
Negative_regulation (reduces) of angiotensin II associated with hypertension
10) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2915917 Disease Relevance 0.98 Pain Relevance 0.25
The most potent inducer of the NADPH oxidase system is angiotensin II,11,12 and there are angiotensin II antagonists in the form of ACE inhibitors, angiotensin II receptor antagonists and direct renin inhibitors (DRA) in clinical use.
Negative_regulation (antagonists) of angiotensin II associated with antagonist
11) Confidence 0.02 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672460 Disease Relevance 0.73 Pain Relevance 0.10
The mechanism of action of captopril, an ACEI, involves suppression of angiotensin II, a potent vasoconstrictor, and increased levels of bradykinin through the inhibition of kininase II, which induces NO release in ECs and stimulates the production of prostacyclin, a vasodilating prostaglandin [117].
Negative_regulation (suppression) of angiotensin II associated with bradykinin
12) Confidence 0.01 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930857 Disease Relevance 0.93 Pain Relevance 0.12
Reflex tachycardia is weak or absent, owing to the following mechanisms: (1) The absence of presynaptic alpha 2-receptor blockade, thus preventing the accelerated release of noradrenaline from the nerve endings; and (2) the blockade of central alpha 1-adrenoceptors, causing a blunting of the reflex tachycardia via the baroreceptor mechanism.
Negative_regulation (blockade) of 2-receptor in nerve associated with heart rate under development and noradrenaline
13) Confidence 0.00 Published 1988 Journal J Hypertens Suppl Section Abstract Doc Link 2906698 Disease Relevance 0.19 Pain Relevance 0.20

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