INT319258

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.26
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Glud1) oxidoreductase activity (Glud1) enzyme binding (Glud1)
cellular amino acid metabolic process (Glud1) cytoplasm (Glud1)
Anatomy Link Frequency
neurons 3
Glud1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 468 100.00 Very High Very High Very High
Central nervous system 28 85.44 High High
Inflammatory response 12 68.88 Quite High
Inflammation 16 62.16 Quite High
Hippocampus 96 55.72 Quite High
Neurotransmitter 24 50.00 Quite Low
anesthesia 4 6.16 Low Low
chemokine 36 5.00 Very Low Very Low Very Low
nMDA receptor 24 5.00 Very Low Very Low Very Low
long-term potentiation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 312 99.96 Very High Very High Very High
Death 40 96.96 Very High Very High Very High
Parkinson's Disease 4 96.56 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 48 92.72 High High
Shock 36 84.64 Quite High
Lifespan 24 80.48 Quite High
Necrosis 4 77.16 Quite High
Apoptosis 24 76.76 Quite High
Stress 96 69.00 Quite High
INFLAMMATION 28 68.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To achieve excess Glu formation in neurons and increased release from synaptic terminals in these animals, the gene for the enzyme glutamate dehydrogenase 1 (Glud1) was introduced under the control of the promoter for neuron-specific enolase (Nse), thus its over-expression occurs only in neurons [14].
Regulation (introduced) of glutamate dehydrogenase 1 in neurons associated with glutamate
1) Confidence 0.45 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.69 Pain Relevance 0.44
To achieve excess Glu formation in neurons and increased release from synaptic terminals in these animals, the gene for the enzyme glutamate dehydrogenase 1 (Glud1) was introduced under the control of the promoter for neuron-specific enolase (Nse), thus its over-expression occurs only in neurons [14].
Regulation (introduced) of Glud1 in neurons associated with glutamate
2) Confidence 0.45 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.69 Pain Relevance 0.41
Although we cannot totally exclude the possibility of minor mitochondrial changes in Glud1 Tg neurons, our transcriptomic analysis did not show observable signs of significant mitochondrial dysfunction at the age probed (9 month).
Spec (possibility) Regulation (changes) of Glud1 in neurons associated with parkinson's disease and targeted disruption
3) Confidence 0.45 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 1.42 Pain Relevance 0.38
Two-way ANOVA of the ratios of PTK2BpY402 to MAP2A labelling (pixel density) in the stratum radiatum of the CA1 region of 5, 10-12, and 19-20 mo-old mice indicated a significant effect of the transgene Glud1 when all ratios across all ages in Glud1 mice were compared with those of the wt (P = 0.002).
Regulation (effect) of Glud1
4) Confidence 0.27 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.46 Pain Relevance 0.03

General Comments

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