INT319263

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Context Info
Confidence 0.73
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.09
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ube3a) nucleus (Ube3a) ligase activity (Ube3a)
Ube3a (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 52 70.40 Quite High
Neurotransmitter 6 50.00 Quite Low
Glutamate 117 38.48 Quite Low
cerebral cortex 24 34.72 Quite Low
chemokine 9 28.00 Quite Low
cytokine 1 6.80 Low Low
Electroencephalography 56 5.00 Very Low Very Low Very Low
Eae 12 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
nMDA receptor 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 94 99.12 Very High Very High Very High
Lifespan 10 96.20 Very High Very High Very High
Cleft Palate 28 92.40 High High
Congenital Anomalies 16 84.68 Quite High
Sprains And Strains 8 82.32 Quite High
Shock 13 71.32 Quite High
Disease 13 69.92 Quite High
Neurodegenerative Disease 6 68.76 Quite High
Angelman Syndrome 220 53.52 Quite High
Stress 48 45.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Generation of mice with a chromosomal deletion from Ube3a to Gabrb3
Localization (deletion) of Ube3a
1) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924885 Disease Relevance 0.19 Pain Relevance 0
Homozygous mutant mice with a deletion from Ube3a to Gabrb3 (m?
Localization (deletion) of Ube3a
2) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924885 Disease Relevance 0.34 Pain Relevance 0
Heterozygous females were bred to wild type C57BL/6J males to produce heterozygotes with a maternal deletion from Ube3a to Gabrb3 (m?
Localization (deletion) of Ube3a
3) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924885 Disease Relevance 0 Pain Relevance 0
Heterozygous males were bred to wild type C57BL/6J females to produce heterozygotes with a paternal deletion from Ube3a to Gabrb3 (m+/p?)
Localization (deletion) of Ube3a
4) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924885 Disease Relevance 0 Pain Relevance 0
In addition to these Ubiquitin-Specific Peptidase genes, the genes for Ubiquitin-Conjugating Enzymes, UBE2K and UBE3A, which covalently attach ubiquitin molecules to proteins destined for degradation, were also up-regulated in Tg mice.
Localization (were) of UBE3A associated with targeted disruption
5) Confidence 0.49 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.57 Pain Relevance 0.04

General Comments

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