INT319274

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.39
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Glud1) oxidoreductase activity (Glud1) enzyme binding (Glud1)
cellular amino acid metabolic process (Glud1) cytoplasm (Glud1)
Anatomy Link Frequency
neurons 4
Glud1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 234 100.00 Very High Very High Very High
Central nervous system 14 85.72 High High
Neurotransmitter 12 50.00 Quite Low
anesthesia 2 6.44 Low Low
Hippocampus 48 5.00 Very Low Very Low Very Low
chemokine 18 5.00 Very Low Very Low Very Low
nMDA receptor 12 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
long-term potentiation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 156 83.20 Quite High
Lifespan 12 80.76 Quite High
Aging 24 67.84 Quite High
Neurodegenerative Disease 12 66.80 Quite High
Embryonic Lethality 2 63.20 Quite High
Disease 26 62.96 Quite High
Attention Deficit Hyperactivity Disorder 24 53.60 Quite High
Tuberous Sclerosis 2 46.96 Quite Low
Toxicity 6 22.12 Low Low
Death 20 12.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To achieve excess Glu formation in neurons and increased release from synaptic terminals in these animals, the gene for the enzyme glutamate dehydrogenase 1 (Glud1) was introduced under the control of the promoter for neuron-specific enolase (Nse), thus its over-expression occurs only in neurons [14].
Regulation (introduced) of Positive_regulation (enzyme) of Glud1 in neurons associated with glutamate
1) Confidence 0.45 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.69 Pain Relevance 0.44
To achieve excess Glu formation in neurons and increased release from synaptic terminals in these animals, the gene for the enzyme glutamate dehydrogenase 1 (Glud1) was introduced under the control of the promoter for neuron-specific enolase (Nse), thus its over-expression occurs only in neurons [14].
Regulation (introduced) of Positive_regulation (enzyme) of glutamate dehydrogenase 1 in neurons associated with glutamate
2) Confidence 0.45 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.69 Pain Relevance 0.44

General Comments

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