INT319293

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Context Info
Confidence 0.80
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.14
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Ptk2b) nucleus (Ptk2b) kinase activity (Ptk2b)
cytoplasm (Ptk2b)
Anatomy Link Frequency
hippocampus 3
neurons 2
brain 1
Ptk2b (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 936 98.78 Very High Very High Very High
Hippocampus 192 98.16 Very High Very High Very High
Pyramidal cell 8 83.04 Quite High
Inflammation 32 81.24 Quite High
nMDA receptor 48 79.00 Quite High
chemokine 93 73.20 Quite High
Neurotransmitter 48 70.64 Quite High
Inflammatory response 24 7.04 Low Low
Central nervous system 56 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 624 98.84 Very High Very High Very High
Injury 64 96.44 Very High Very High Very High
Stress 192 90.60 High High
Adhesions 99 88.08 High High
Nervous System Malformation 64 83.16 Quite High
Aging 96 82.64 Quite High
INFLAMMATION 56 81.24 Quite High
Carcinoma 25 62.12 Quite High
Breast Cancer 4 61.68 Quite High
Wiskott-aldrich Syndrome 8 57.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether the events associated with PTK2B-mediated neurite growth are indeed more pronounced under the conditions of chronically increased Glu activity in brain, we probed for evidence of changes in the phosphorylation status of PTK2B, as well as for changes in total protein levels of PTK2B in Glud1 mice.
Phosphorylation (phosphorylation) of PTK2B in brain associated with glutamate
1) Confidence 0.80 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0 Pain Relevance 0.18
In addition to the PTK2B labelling in dendrites, the levels of the phosphorylated form of PTK2B, PTK2BpY402, were also well preserved in the CA1 region of the hippocampus from Glud1 mice (Figure 3D, H).
Phosphorylation (phosphorylated) of PTK2B in hippocampus associated with hippocampus
2) Confidence 0.80 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.30 Pain Relevance 0.16
In addition to the PTK2B labelling in dendrites, the levels of the phosphorylated form of PTK2B, PTK2BpY402, were also well preserved in the CA1 region of the hippocampus from Glud1 mice (Figure 3D, H).
Phosphorylation (phosphorylated) of PTK2BpY402 in hippocampus associated with hippocampus
3) Confidence 0.80 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.31 Pain Relevance 0.16
We determined that the gene and the activated form of this protein, the phosphorylated PTK2B, were up-regulated in Glud1 Tg hippocampal neurons that are normally susceptible to the injury that results from hyper-glutamatergic activity.
Phosphorylation (phosphorylated) of PTK2B in neurons associated with targeted disruption and injury
4) Confidence 0.61 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 1.14 Pain Relevance 0.20
This translocation depends on its biochemical activation via auto-phosphorylation on Tyr 402 (PTK2BpY402), which is further dependent on the state of Ca2+ signaling in neurons [55].
Phosphorylation (phosphorylation) of PTK2BpY402 in neurons
5) Confidence 0.61 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.06 Pain Relevance 0.18
Overall, the immunohistochemical characterization of PTK2B and phospho-PTK2B levels in hippocampal neurons indicated that not only protein levels but also biochemical activation (i.e., phosphorylation) of PTK2B were significantly increased in the Tg mouse hippocampus.
Phosphorylation (phosphorylation) of PTK2B in hippocampus associated with targeted disruption and hippocampus
6) Confidence 0.61 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.38 Pain Relevance 0.05
Immunohistochemical labelling with anti-PTK2B pan-antibodies and selective antibodies against the phosphorylated form of PTK2B was performed in 10-12 mo-old mice, an age very close to the 9 mo-old mice used for the microarray analyses.
Phosphorylation (phosphorylated) of PTK2B
7) Confidence 0.61 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0 Pain Relevance 0.13
Immunohistochemical labelling with anti-PTK2B pan-antibodies and selective antibodies against the phosphorylated form of PTK2B was performed in 10-12 mo-old mice, an age very close to the 9 mo-old mice used for the microarray analyses.
Phosphorylation (form) of PTK2B
8) Confidence 0.61 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0 Pain Relevance 0.12
We determined that phosphorylation of paxillin, FAK, p130Cas, and to a lesser extent Pyk2, decreased rapidly and preceded diminishment in total cellular levels of those proteins in CXCL12-expressing cells (Figure 2A).
Phosphorylation (phosphorylation) of Pyk2
9) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.96 Pain Relevance 0.06

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