INT319312

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.68
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk8) cytoplasm (Mapk8) cytosol (Mapk8)
signal transduction (Mapk8) nucleus (Mapk8) molecular_function (Socs4)
Anatomy Link Frequency
Ptk2 1
Socs4 (Mus musculus)
Mapk8 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 1 100.00 Very High Very High Very High
chemokine 9 98.84 Very High Very High Very High
Inflammatory response 3 85.28 High High
cytokine 1 83.28 Quite High
Hippocampus 24 51.56 Quite High
Neurotransmitter 6 50.00 Quite Low
Glutamate 117 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
nMDA receptor 6 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 24 100.00 Very High Very High Very High
Adhesions 8 100.00 Very High Very High Very High
INFLAMMATION 7 84.88 Quite High
Targeted Disruption 78 80.92 Quite High
Alzheimer's Dementia 1 33.68 Quite Low
Disease 13 30.08 Quite Low
Injury 8 12.96 Low Low
Aging 12 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 12 5.00 Very Low Very Low Very Low
Death 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The genes included in the Chemokine signalling pathway (Table 2) were those of post-receptor signalling and included genes for the focal adhesion kinases Ptk2b (Protein Tyrosine Kinase 2 Beta) and Ptk2 (Protein Tyrosine Kinase 2), calcium-diacylglycerol-activated protein kinase C alpha (Prkca), stress kinases Mapk8 and Mapk14, and the calcium/calmodulin-dependent protein kinases Camk2a and Camk2b.
signalling Positive_regulation (activated) of Mapk8 in Ptk2 associated with stress, chemokine, kinase c and adhesions
1) Confidence 0.05 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.68 Pain Relevance 0.41

General Comments

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