INT31940

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Context Info
Confidence 0.35
First Reported 1988
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.16
Pain Relevance 3.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FCGR1A) plasma membrane (FCGR1A)
Anatomy Link Frequency
brain 2
FCGR1A (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 11 100.00 Very High Very High Very High
adenocard 24 99.98 Very High Very High Very High
abatacept 3 99.98 Very High Very High Very High
noradrenaline 3 99.84 Very High Very High Very High
Opioid 2 99.40 Very High Very High Very High
Inflammation 6 98.56 Very High Very High Very High
Etanercept 12 98.14 Very High Very High Very High
spinal inflammation 1 95.80 Very High Very High Very High
Arthritis 6 94.68 High High
psoriasis 50 94.20 High High
Disease Link Frequency Relevance Heat
Necrosis 4 99.10 Very High Very High Very High
Cancer 8 98.92 Very High Very High Very High
INFLAMMATION 6 98.56 Very High Very High Very High
Low Back Pain 1 95.80 Very High Very High Very High
Seronegative Spondarthritis 6 94.68 High High
Psoriasis 58 94.20 High High
Rheumatoid Arthritis 16 93.84 High High
Hyperinsulinism 1 83.36 Quite High
Disease 13 70.00 Quite High
Infection 12 55.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Abatacept binds to the Fc receptor CD64 but does not mediate complement-dependent cytotoxicity or antibody-dependent cellular cytotoxicity.
CD64 Binding (binds) of associated with abatacept
1) Confidence 0.35 Published 2007 Journal J. Rheumatol. Section Title Doc Link 17787038 Disease Relevance 0 Pain Relevance 0.28
In membranes prepared from trout whole brain, the A1 receptor agonist [(3)H]CHA bound saturably, reversibly and with high affinity (K(d)=0. 69+/-0.04 nM; B(max)=0.624+/-0.012 pmol/mg protein) to a single class of binding sites.
A1 receptor Binding (bound) of in brain associated with agonist
2) Confidence 0.04 Published 1999 Journal Brain Res. Section Abstract Doc Link 10433987 Disease Relevance 0 Pain Relevance 0.47
Etanercept is a human fusion protein of the tumor necrosis factor receptor (TNFR) and the Fc region of IgG1 that binds to and presumably inhibits the pro-inflammatory and pro-proliferative activity of the tumor necrosis factor (TNF).
IgG1 Binding (binds) of associated with necrosis, inflammation, cancer and etanercept
3) Confidence 0.04 Published 2004 Journal J Drugs Dermatol Section Abstract Doc Link 15176161 Disease Relevance 1.08 Pain Relevance 0.60
It is a fusion protein composed of human TNF type II receptor (TNF-Rp75) and human IgG1 Fc Region, which binds to soluble TNF-?
IgG1 Fc Region Binding (binds) of
4) Confidence 0.02 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504074 Disease Relevance 1.00 Pain Relevance 0.69
The CHA effect (even the maximum effect at 50 microM) can be increased by 10 microM NECA indicating that CHA and NECA have nonspecific and physiologically non-relevant effects on 86Rb+ efflux in addition to their A1-receptor interaction.
A1-receptor Binding (interaction) of
5) Confidence 0.02 Published 2008 Journal Cell Biochem. Funct. Section Abstract Doc Link 18979526 Disease Relevance 0.08 Pain Relevance 0.45
Presynaptic alpha 2-adrenoceptor, opioid kappa-receptor and adenosine A1-receptor interactions on noradrenaline release in rabbit brain cortex.
A1-receptor Binding (interactions) of in brain associated with adenocard, noradrenaline and opioid
6) Confidence 0.01 Published 1988 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 2907100 Disease Relevance 0 Pain Relevance 0.62

General Comments

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