INT31949

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Context Info
Confidence 0.05
First Reported 1988
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 4.00
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (PIF1) helicase activity (PIF1) DNA binding (PIF1)
Anatomy Link Frequency
lymphocytes 1
brain 1
PIF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 8 99.88 Very High Very High Very High
Pain 11 99.62 Very High Very High Very High
Opioid 2 99.06 Very High Very High Very High
Morphine 7 98.66 Very High Very High Very High
Shingles 16 98.44 Very High Very High Very High
Dopamine 2 93.88 High High
iatrogenic 2 83.36 Quite High
narcan 2 65.68 Quite High
depression 10 5.00 Very Low Very Low Very Low
cerebral cortex 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Herpes Zoster 222 100.00 Very High Very High Very High
Cv Unclassified Under Development 7 99.88 Very High Very High Very High
Depression 16 99.28 Very High Very High Very High
Myocardial Infarction 2 96.12 Very High Very High Very High
Infection 6 66.64 Quite High
Coronary Artery Disease 1 65.60 Quite High
Pain 10 63.60 Quite High
Herpes Simplex Virus 4 50.20 Quite High
Communicable Diseases 18 48.00 Quite Low
Sleep Disorders 4 39.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine and related opioids may indirectly stimulate prolactin release by inhibiting PIF release and (or) by stimulating putative PRF release.
Negative_regulation (inhibiting) of PIF associated with opioid and morphine
1) Confidence 0.05 Published 1988 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 2907416 Disease Relevance 0 Pain Relevance 0.68
And indeed, the only way to do so is to physically split the brain in two to prevent information integration between the two hemispheres.
Negative_regulation (prevent) of integration in brain
2) Confidence 0.02 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC543470 Disease Relevance 0 Pain Relevance 0
Moreover, the presence of depressive symptoms in older adults is associated with declines in VZV-responder cell frequency (VZV-RCF), an immunological marker of shingles risk.
Negative_regulation (declines) of VZV-responder cell frequency associated with depression, herpes zoster and shingles
3) Confidence 0.00 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Abstract Doc Link PMC538519 Disease Relevance 0.99 Pain Relevance 0.13
Age-related decline in VZV-responder cell frequency (RCF; frequency of lymphocytes that proliferate in response to VZV antigen) is temporally related to an increase in the incidence and severity of HZ and its complications in older rats (7,8,11–14).
Negative_regulation (decline) of VZV-responder cell frequency in lymphocytes associated with herpes zoster
4) Confidence 0.00 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538519 Disease Relevance 2.15 Pain Relevance 0.07
Spectral analysis of CRV revealed that in painful ischemia (PI) the total frequency (TF) of waves significantly decreased by 22%.
Negative_regulation (decreased) of total frequency associated with pain and ischemia
5) Confidence 0.00 Published 2003 Journal Klin Med (Mosk) Section Abstract Doc Link 14664168 Disease Relevance 0.86 Pain Relevance 0.50

General Comments

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