INT31949

Context Info Confidence 0.05 First Reported 1988 Last Reported 2004 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 5 Disease Relevance 4.00 Pain Relevance 1.38

nucleus (PIF1) helicase activity (PIF1) DNA binding (PIF1)

Anatomy Link Frequency lymphocytes 1 brain 1 PIF1 (Homo sapiens)

Pain Link Frequency Relevance Heat ischemia 8 99.88 Pain 11 99.62 Opioid 2 99.06 Morphine 7 98.66 Shingles 16 98.44 Dopamine 2 93.88 iatrogenic 2 83.36 narcan 2 65.68 depression 10 5.00 cerebral cortex 4 5.00

Disease Link Frequency Relevance Heat Herpes Zoster 222 100.00 Cv Unclassified Under Development 7 99.88 Depression 16 99.28 Myocardial Infarction 2 96.12 Infection 6 66.64 Coronary Artery Disease 1 65.60 Pain 10 63.60 Herpes Simplex Virus 4 50.20 Communicable Diseases 18 48.00 Sleep Disorders 4 39.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Morphine and related opioids may indirectly stimulate prolactin release by inhibiting PIF release and (or) by stimulating putative PRF release.

Negative_regulation (inhibiting) of PIF associated with opioid and morphine

1) Confidence 0.05 Published 1988 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 2907416 Disease Relevance 0 Pain Relevance 0.68

And indeed, the only way to do so is to physically split the brain in two to prevent information integration between the two hemispheres.

Negative_regulation (prevent) of integration in brain

2) Confidence 0.02 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC543470 Disease Relevance 0 Pain Relevance 0

Moreover, the presence of depressive symptoms in older adults is associated with declines in VZV-responder cell frequency (VZV-RCF), an immunological marker of shingles risk.

Negative_regulation (declines) of VZV-responder cell frequency associated with depression, herpes zoster and shingles

3) Confidence 0.00 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Abstract Doc Link PMC538519 Disease Relevance 0.99 Pain Relevance 0.13

Age-related decline in VZV-responder cell frequency (RCF; frequency of lymphocytes that proliferate in response to VZV antigen) is temporally related to an increase in the incidence and severity of HZ and its complications in older rats (7,8,11–14).

Negative_regulation (decline) of VZV-responder cell frequency in lymphocytes associated with herpes zoster

4) Confidence 0.00 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538519 Disease Relevance 2.15 Pain Relevance 0.07

Spectral analysis of CRV revealed that in painful ischemia (PI) the total frequency (TF) of waves significantly decreased by 22%.

Negative_regulation (decreased) of total frequency associated with pain and ischemia

5) Confidence 0.00 Published 2003 Journal Klin Med (Mosk) Section Abstract Doc Link 14664168 Disease Relevance 0.86 Pain Relevance 0.50

General Comments

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