INT319540

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Context Info
Confidence 0.49
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 10
Disease Relevance 2.94
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Angptl4) extracellular space (Angptl4) extracellular region (Angptl4)
proteinaceous extracellular matrix (Angptl4)
Anatomy Link Frequency
gut 5
fat 1
F19 1
Angptl4 (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 1 99.84 Very High Very High Very High
agonist 10 97.40 Very High Very High Very High
addiction 14 95.32 Very High Very High Very High
Opioid 7 79.44 Quite High
imagery 90 78.88 Quite High
antagonist 8 74.00 Quite High
cocaine 19 67.76 Quite High
Morphine 18 62.32 Quite High
Glutamate receptor 1 7.00 Low Low
anesthesia 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 108 100.00 Very High Very High Very High
Diabetes Mellitus 9 95.20 Very High Very High Very High
Stress 8 94.76 High High
Dyslipidemia /

Combined Dyslipidemia

9 94.40 High High
Overweight 27 89.88 High High
Weight Gain 27 79.00 Quite High
Weight Loss 18 76.20 Quite High
Disease 10 75.56 Quite High
Sprains And Strains 27 73.96 Quite High
Chronic Disease 9 58.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pattern B genes modulate various aspects of cell functioning: hexose transport (Slc2a1), lipid metabolism (Angptl4, Pparg), regulation of sodium channels and the actin cytoskeleton (Sgk1) and regulation of the cell cycle (Cdkn1a), to mention just a few [81-84].
Regulation (regulation) of Angptl4 associated with sodium channel
1) Confidence 0.49 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.09 Pain Relevance 0.41
It was suggested that a conventional whole gut flora down regulated intestinal ANGPTL4, which promoted adiposity [6], [7].
Regulation (regulated) of ANGPTL4 in gut
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.63 Pain Relevance 0.04
Taken together, these data suggest that the Lactobacillus F19 secreted, as yet uncharacterized, heat stable molecules could be responsible for the observed effects on ANGPTL4.
Regulation (responsible) of ANGPTL4 in F19
3) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.19 Pain Relevance 0
In the current study, we examined the possibility that probiotic bacteria could target the fat storage regulator ANGPTL4 and, as a consequence, execute its modulatory effects.
Regulation (target) of ANGPTL4 in fat
4) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.28 Pain Relevance 0
ANGPTL4 is a target gene of the PPARs [18] which was confirmed by specific ligand stimulation.
Regulation (target) of ANGPTL4
5) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.18 Pain Relevance 0
Angiopoietin-like 4 (ANGPTL4) is a circulating lipoprotein lipase (LPL) inhibitor that controls triglyceride deposition into adipocytes and has been reported to be regulated by gut microbes.


Regulation (regulated) of Angiopoietin-like 4 in gut associated with obesity
6) Confidence 0.27 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2948012 Disease Relevance 0.19 Pain Relevance 0.04
ANGPTL4 is also a downstream target gene of peroxisome proliferator activated receptors (PPAR), the agonists of which are widely used for the treatment of type 2 diabetes and dyslipidemia [4], [5].
Regulation (target) of ANGPTL4 associated with diabetes mellitus and agonist
7) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.91 Pain Relevance 0.05
Our results provide an interesting mechanism whereby modifying ANGPTL4, a central player in fat storage regulation, through manipulating gut flora could be an important gateway upon which intervention trials of weight management can be based.



Regulation (regulation) of ANGPTL4 in gut
8) Confidence 0.27 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2948012 Disease Relevance 0 Pain Relevance 0.03
Our results open the intriguing possibility that modifying LPL activity through ANGPTL4, central to fat storage regulation, by manipulating the gut flora could be one important mechanism by which various interventions may modulate body fat storage.


Regulation (regulation) of ANGPTL4 in gut
9) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.09 Pain Relevance 0.03
Angiopoietin-like 4 (ANGPTL4) is a circulating lipoprotein lipase (LPL) inhibitor that controls triglyceride deposition into adipocytes and has been reported to be regulated by gut microbes.


Regulation (regulated) of ANGPTL4 in gut associated with obesity
10) Confidence 0.27 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2948012 Disease Relevance 0.19 Pain Relevance 0.04

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