INT31955

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.96
First Reported 1981
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 2.95
Pain Relevance 3.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (MET) signal transduction (MET) plasma membrane (MET)
Anatomy Link Frequency
putamen 1
Hippocampus 1
MET (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 36 100.00 Very High Very High Very High
Endogenous opioid 1 96.48 Very High Very High Very High
Hippocampus 10 95.40 Very High Very High Very High
Opioid 4 92.60 High High
Dynorphin 2 84.32 Quite High
Cholecystokinin 1 75.00 Quite High
Bioavailability 2 50.08 Quite High
alcohol 12 24.44 Low Low
fibrosis 6 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cirrhosis 114 99.44 Very High Very High Very High
Chronic Hepatitis 62 98.84 Very High Very High Very High
Dog Diseases 2 91.44 High High
Fibrosis 18 90.80 High High
Hepatitis 66 80.24 Quite High
Liver Disease 24 70.20 Quite High
Hepatitis C Virus Infection 14 27.60 Quite Low
Infection 10 26.48 Quite Low
Alcohol Addiction 6 24.68 Low Low
Disease 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purified placental aminopeptidase M actively degraded Met-enkephalin (Met-Enk) and Leu-enkephalin (Leu-Enk) completely into constituent 5 amino acids.
Protein_catabolism (degraded) of Met associated with enkephalin
1) Confidence 0.96 Published 1988 Journal Exp. Clin. Endocrinol. Section Abstract Doc Link 2907492 Disease Relevance 0 Pain Relevance 0.41
The protease inhibitors bestatin and bacitracin had but little effect on the degradation of Met-Enk.
Protein_catabolism (degradation) of Met
2) Confidence 0.96 Published 1987 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 3037971 Disease Relevance 0 Pain Relevance 0.34
Hippocampus and putamen samples from both brains showed similar Km (mean 25.2, muM; range, 23.3-27.2 mum), Vmax (mean 108 nmol/mg protein/minute; range, 103-115 nmol/mg), and IC50 values (bacitracin, mean 14.4 muM; range, 13.8-14.7 mum) for MET AP degradation.
Protein_catabolism (degradation) of MET in putamen associated with enkephalin and hippocampus
3) Confidence 0.96 Published 2009 Journal Am J Ther Section Abstract Doc Link 19797941 Disease Relevance 0 Pain Relevance 0.72
The purified placental aminopeptidase M actively degraded Met-enkephalin (Met-Enk) and Leu-enkephalin (Leu-Enk) completely into constituent 5 amino acids.
Protein_catabolism (degraded) of Met associated with enkephalin
4) Confidence 0.86 Published 1988 Journal Exp. Clin. Endocrinol. Section Abstract Doc Link 2907492 Disease Relevance 0 Pain Relevance 0.41
Leu- and met-enkephalins were degraded at the same rate while their N-terminal tri- and dipeptides were hydrolysed more slowly.
Protein_catabolism (degraded) of met associated with enkephalin
5) Confidence 0.64 Published 1981 Journal Peptides Section Abstract Doc Link 6283489 Disease Relevance 0 Pain Relevance 0.46
The reduced c-MET protein levels indicate a utilization of c-MET which is degraded through endocytosis after phosphorylation.
Protein_catabolism (degraded) of c-MET protein
6) Confidence 0.43 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.49 Pain Relevance 0
Hippocampus and putamen samples from both brains showed similar Km (mean 25.2, muM; range, 23.3-27.2 mum), Vmax (mean 108 nmol/mg protein/minute; range, 103-115 nmol/mg), and IC50 values (bacitracin, mean 14.4 muM; range, 13.8-14.7 mum) for MET AP degradation.
Protein_catabolism (degradation) of MET in Hippocampus associated with enkephalin and hippocampus
7) Confidence 0.33 Published 2009 Journal Am J Ther Section Abstract Doc Link 19797941 Disease Relevance 0 Pain Relevance 0.72
The reduced c-MET protein levels indicate a utilization of c-MET which is degraded through endocytosis after phosphorylation.
Protein_catabolism (degraded) of c-MET
8) Confidence 0.32 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.46 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox