INT319578

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.56
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP3A4) oxidoreductase activity (CYP3A4) endoplasmic reticulum (CYP3A4)
plasma membrane (ALPPL2) enzyme binding (CYP3A4) lipid metabolic process (CYP3A4)
CYP3A4 (Homo sapiens)
ALPPL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
carbamazepine 13 97.96 Very High Very High Very High
imagery 14 5.00 Very Low Very Low Very Low
Lamotrigine 9 5.00 Very Low Very Low Very Low
Gabapentin 7 5.00 Very Low Very Low Very Low
antiepileptic Drug 3 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
hyperexcitability 1 5.00 Very Low Very Low Very Low
sodium channel 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
deep brain stimulation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Partial Seizures 59 88.40 High High
Convulsion 109 80.08 Quite High
Epilepsy 72 64.44 Quite High
Toxicity 4 46.32 Quite Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Head Trauma 4 5.00 Very Low Very Low Very Low
Dystonia 3 5.00 Very Low Very Low Very Low
Neurological Disease 3 5.00 Very Low Very Low Very Low
Frailty 3 5.00 Very Low Very Low Very Low
Confusion 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Grapefruit inhibits CYP3A4, a P450 isozyme important in the metabolism of some of the benzodiazepines, CBZ, TGB, and ZNS.54
CYP3A4 Regulation (important) of P450 isozyme associated with carbamazepine
1) Confidence 0.00 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2898168 Disease Relevance 0.56 Pain Relevance 0.05

General Comments

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