INT319581

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.58
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PIAS1) enzyme binding (PIAS1) DNA binding (PIAS1)
cytoplasm (TNFSF14) ligase activity (PIAS1) signal transduction (TNFSF14)
PIAS1 (Homo sapiens)
TNFSF14 (Homo sapiens)
Pain Link Frequency Relevance Heat
carbamazepine 26 100.00 Very High Very High Very High
Lamotrigine 18 100.00 Very High Very High Very High
Gabapentin 14 100.00 Very High Very High Very High
headache 4 86.08 High High
depression 2 81.44 Quite High
imagery 28 18.04 Low Low
antiepileptic Drug 6 5.00 Very Low Very Low Very Low
hyperexcitability 2 5.00 Very Low Very Low Very Low
sodium channel 2 5.00 Very Low Very Low Very Low
deep brain stimulation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 218 90.24 High High
Fatigue 4 86.96 High High
Headache 4 86.08 High High
Depression 2 81.44 Quite High
Partial Seizures 118 80.28 Quite High
Exanthema 2 72.72 Quite High
Epilepsy 144 53.36 Quite High
Frailty 6 23.88 Low Low
Toxicity 8 5.00 Very Low Very Low Very Low
Congenital Anomalies 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LTG was significantly better than CBZ, GBP, and TPM and had a nonsignificant advantage over OXC in the time to treatment failure measure, but CBZ was significantly better than GBP and had a nonsignificant advantage over LTG, TPM, and OXC in time to 12-month remission.46 About 50% of patients reported side effects at some point in the study, but differences among AEDs were not large.
GBP Binding (better) of LTG associated with lamotrigine, gabapentin and carbamazepine
1) Confidence 0.02 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2898168 Disease Relevance 0.75 Pain Relevance 1.06
LTG was significantly better than CBZ, GBP, and TPM and had a nonsignificant advantage over OXC in the time to treatment failure measure, but CBZ was significantly better than GBP and had a nonsignificant advantage over LTG, TPM, and OXC in time to 12-month remission.46 About 50% of patients reported side effects at some point in the study, but differences among AEDs were not large.
GBP Binding (advantage) of LTG associated with lamotrigine, gabapentin and carbamazepine
2) Confidence 0.02 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2898168 Disease Relevance 0.82 Pain Relevance 1.07

General Comments

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