INT319656

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Context Info
Confidence 0.55
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.89
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Gadd45gip1, Nfe2l2) mitochondrion (Gadd45gip1) plasma membrane (Nfe2l2)
DNA binding (Nfe2l2) cell cycle (Gadd45gip1) cytoplasm (Nfe2l2)
Gadd45gip1 (Mus musculus)
Nfe2l2 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 92 98.56 Very High Very High Very High
Cancer 24 80.04 Quite High
Targeted Disruption 12 43.32 Quite Low
Death 4 42.52 Quite Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Aging 4 5.00 Very Low Very Low Very Low
Chronic Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We hypothesized that CRIF1 could negatively regulate NRF2 target gene expression at the chromosomal level by affecting NRF2 accumulation at ARE-containing regions of NRF2 target gene promoters and enhancers.
CRIF1 Regulation (regulate) of Gene_expression (expression) of NRF2
1) Confidence 0.55 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0 Pain Relevance 0
It is tempting to speculate that this greater range of CRIF1-NRF2 interactions is somehow related to the greater range of conditions under which CRIF1 can negatively regulate NRF2 protein levels and thus NRF2 target gene expression.
CRIF1 Regulation (regulate) of Gene_expression (expression) of NRF2
2) Confidence 0.55 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0.39 Pain Relevance 0
It is tempting to speculate that this greater range of CRIF1-NRF2 interactions is somehow related to the greater range of conditions under which CRIF1 can negatively regulate NRF2 protein levels and thus NRF2 target gene expression.
CRIF1 Regulation (regulate) of Gene_expression (expression) of NRF2
3) Confidence 0.41 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0.39 Pain Relevance 0
Because the effects of CRIF1 on NRF2 protein levels and NRF2 target gene expression, under both reducing and oxidative stress conditions, are predictable, we hypothesized that altered CRIF1 protein levels might also affect the accumulation of certain types of ROS in a predictable manner.
CRIF1 Regulation (effects) of Gene_expression (expression) of NRF2 associated with stress
4) Confidence 0.24 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0.10 Pain Relevance 0

General Comments

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