INT319657

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Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.17
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Nfe2l2, Gopc) cytoplasm (Nfe2l2, Gopc) transport (Gopc)
Golgi apparatus (Gopc) nucleus (Nfe2l2) DNA binding (Nfe2l2)
Nfe2l2 (Mus musculus)
Gopc (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 69 89.12 High High
Cancer 18 5.00 Very Low Very Low Very Low
Targeted Disruption 9 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Aging 3 5.00 Very Low Very Low Very Low
Chronic Disease 3 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both slower and faster migrating forms of CRIF1 IVT seem to interact with NRF2 not only in vitro but also in vivo (Fig. 1, C and D).
NRF2 Binding (interact) of Fig
1) Confidence 0.10 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0 Pain Relevance 0
Because CRIF1 can bind the N- and C-terminal region of NRF2 (Fig. 2C), we tested whether CRIF1 can also drive ubiquitination at the C terminus of NRF2.
NRF2 Binding (bind) of Fig
2) Confidence 0.07 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0 Pain Relevance 0
This experiment showed that endogenous CRIF1, like exogenous CRIF1, can interact with NRF2 in the absence or presence of either of two NRF2-inducing agents (Fig. 1, C and D), indicating that the CRIF1-NRF2 interaction is redox-independent.
NRF2 Binding (interact) of Fig
3) Confidence 0.07 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0.17 Pain Relevance 0

General Comments

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