INT319666

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Context Info
Confidence 0.55
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 15
Disease Relevance 2.23
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Gadd45gip1, Nfe2l2) mitochondrion (Gadd45gip1) plasma membrane (Nfe2l2)
DNA binding (Nfe2l2) cell cycle (Gadd45gip1) cytoplasm (Nfe2l2)
Gadd45gip1 (Mus musculus)
Nfe2l2 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 345 99.16 Very High Very High Very High
Chronic Disease 15 84.88 Quite High
Cancer 90 80.04 Quite High
Targeted Disruption 45 43.32 Quite Low
Death 15 42.52 Quite Low
Sprains And Strains 15 5.00 Very Low Very Low Very Low
Aging 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because CRIF1 and NRF2 interact, we tested whether CRIF1 can affect NRF2 protein levels under normal reducing conditions.
CRIF1 Regulation (affect) of NRF2
1) Confidence 0.55 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0 Pain Relevance 0
However, the most important difference between CRIF1 and KEAP1 negative regulation of NRF2 may have physiological significance, i.e. the unique ability of CRIF1 (but not KEAP1) to negatively regulate NRF2 protein levels under conditions of oxidative stress.
CRIF1 Regulation (regulate) of NRF2 associated with stress
2) Confidence 0.55 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0.26 Pain Relevance 0
Both CRIF1 and KEAP1 1) function at the post-transcription level; 2) regulate NRF2 protein levels by binding the N-terminal region of NRF2; 3) promote ubiquitination of the same cluster of N-terminal NRF2 lysine residues; 4) promote proteasome-mediated degradation of NRF2; and 5) function under the reducing conditions normally present in cells.
CRIF1 Regulation (regulate) of NRF2
3) Confidence 0.55 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0.23 Pain Relevance 0
It is tempting to speculate that this greater range of CRIF1-NRF2 interactions is somehow related to the greater range of conditions under which CRIF1 can negatively regulate NRF2 protein levels and thus NRF2 target gene expression.
CRIF1 Regulation (regulate) of NRF2
4) Confidence 0.55 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0.39 Pain Relevance 0
To test whether endogenous CRIF1 negatively regulates endogenous NRF2 protein levels, we first reduced the negative regulation of endogenous NRF2 of CRIF1 by using CRIF1-specific siRNAs.
CRIF1 Spec (whether) Regulation (regulates) of NRF2
5) Confidence 0.41 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0 Pain Relevance 0
Each inhibitor increased NRF2 protein levels, indicating that CRIF1, like KEAP1, negatively regulates NRF2 protein levels by affecting its stability, at least under normal reducing conditions.
CRIF1 Regulation (regulates) of NRF2
6) Confidence 0.41 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0 Pain Relevance 0
Here, we show that CRIF1, a protein previously known as cell cycle regulator and transcription cofactor, is also able to negatively regulate NRF2 protein stability.
CRIF1 Regulation (regulate) of NRF2
7) Confidence 0.24 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2898415 Disease Relevance 0.44 Pain Relevance 0
Thus, we found that NRF2 stability is significantly affected by the presence of CRIF1.


CRIF1 Regulation (affected) of NRF2
8) Confidence 0.24 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0 Pain Relevance 0
However, the most important difference between CRIF1 and KEAP1 negative regulation of NRF2 may have physiological significance, i.e. the unique ability of CRIF1 (but not KEAP1) to negatively regulate NRF2 protein levels under conditions of oxidative stress.
CRIF1 Regulation (regulation) of NRF2 associated with stress
9) Confidence 0.24 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0.21 Pain Relevance 0
Are CRIF1 and KEAP1 negative regulations of NRF2 completely independent of one another?
CRIF1 Regulation (regulations) of NRF2
10) Confidence 0.24 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0.15 Pain Relevance 0
Thus, by eliminating the negative regulation of KEAP1 for NRF2 for at least 4 h, we were able to easily detect the ability of endogenous CRIF1 to negatively regulate endogenous NRF2 protein levels (Fig. 3C).
CRIF1 Regulation (regulate) of NRF2
11) Confidence 0.24 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0 Pain Relevance 0
To test whether exogenous CRIF1 can affect NRF2 and NRF2 target gene mRNA levels when functional KEAP1-NRF2 interactions are eliminated, cells were infected with adenovirus (GFP versus GFP-CRIF1) (19) for 24 h and then treated with t-BHQ (100 ?
CRIF1 Regulation (affect) of NRF2
12) Confidence 0.24 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0.06 Pain Relevance 0
However, in contrast to KEAP1, which regulates NRF2 stability only under normal reducing conditions, CRIF1 regulates NRF2 stability and its target gene expression under both reducing and oxidative stress conditions.
CRIF1 Regulation (regulates) of NRF2 associated with stress
13) Confidence 0.24 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2898415 Disease Relevance 0.43 Pain Relevance 0
Thus, these results are consistent with the notion that endogenous CRIF1 protein levels also negatively regulate NRF2 protein levels.
CRIF1 protein Regulation (regulate) of NRF2
14) Confidence 0.24 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0 Pain Relevance 0
To test whether exogenous CRIF1 can affect NRF2 and NRF2 target gene mRNA levels when functional KEAP1-NRF2 interactions are eliminated, cells were infected with adenovirus (GFP versus GFP-CRIF1) (19) for 24 h and then treated with t-BHQ (100 ?
CRIF1 Regulation (affect) of NRF2
15) Confidence 0.11 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0.06 Pain Relevance 0

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