INT319687

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.66
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Gadd45gip1, Nfe2l2) mitochondrion (Gadd45gip1) plasma membrane (Nfe2l2)
DNA binding (Nfe2l2) cell cycle (Gadd45gip1) cytoplasm (Nfe2l2)
Gadd45gip1 (Mus musculus)
Nfe2l2 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 12 97.84 Very High Very High Very High
Stress 46 91.40 High High
Targeted Disruption 6 61.12 Quite High
Death 2 60.32 Quite High
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low
Chronic Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A second notable difference between KEAP1 and CRIF1 negative regulation of NRF2 is that KEAP1 can bind to, ubiquitinate, and drive proteasomal degradation of full-length NRF2 only at the N-terminal region of NRF2, whereas CRIF1 can bind and ubiquitinate and may drive proteasomal degradation of full-length NRF2 through both ends of the protein.
CRIF1 Negative_regulation (regulation) of NRF2
1) Confidence 0.39 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0.66 Pain Relevance 0
Because more endogenous NRF2 accumulated in the CRIF1 knockdown cells (treated with SFN) than in the control cells (also treated with SFN), it is clear that endogenous CRIF1 acts as a negative regulator of endogenous NRF2 protein.
CRIF1 Negative_regulation (regulator) of NRF2
2) Confidence 0.38 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0 Pain Relevance 0

General Comments

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