INT319718

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Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.68
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Crebbp, Creb1) DNA binding (Crebbp, Creb1) transcription factor binding (Crebbp, Creb1)
nucleoplasm (Creb1) cell proliferation (Crebbp) mitochondrion (Creb1)
Anatomy Link Frequency
Lung 1
Crebbp (Rattus norvegicus)
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 116 96.48 Very High Very High Very High
cva 8 72.00 Quite High
ischemia 24 52.24 Quite High
cytokine 12 25.04 Quite Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Restless leg syndrome 4 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 92 96.48 Very High Very High Very High
Hemorrhagic Shock 92 90.52 High High
Pneumonia 28 79.16 Quite High
Hemorrhage 12 72.00 Quite High
Shock 32 61.96 Quite High
Cv Unclassified Under Development 24 52.24 Quite High
Reperfusion Injury 16 51.52 Quite High
Injury 28 6.32 Low Low
Adult Respiratory Distress Syndrome 32 5.00 Very Low Very Low Very Low
Lung Injury 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, CREB-CBP binding was favored with HSPTX resuscitation, potentially accounting for the difference in pro-inflammatory mediator synthesis observed with different resuscitation modalities.
CBP Binding (binding) of CREB associated with inflammation
1) Confidence 0.10 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2898548 Disease Relevance 0.46 Pain Relevance 0.20
Given that an increased association between CBP and CREB was evident with HSPTX, we sought to determine whether CREB-DNA binding was upregulated.
CBP Binding (association) of CREB
2) Confidence 0.09 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2898548 Disease Relevance 0.61 Pain Relevance 0.14
Interactions between CBP and CREB or p65 were demonstrated with a modification of the method reported by Gerritsen and coworkers.21 Lung nuclear extracts (10 ?
CBP Binding (Interactions) of CREB in Lung
3) Confidence 0.09 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2898548 Disease Relevance 0 Pain Relevance 0
Given that an increased association between CBP and CREB was evident with HSPTX, we sought to determine whether CREB-DNA binding was upregulated.
CBP Binding (association) of CREB
4) Confidence 0.09 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2898548 Disease Relevance 0.61 Pain Relevance 0.14

General Comments

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