INT319724

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Context Info
Confidence 0.16
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 4.19
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Crebbp) nucleus (Crebbp) DNA binding (Crebbp)
protein complex (Crebbp) transcription factor binding (Crebbp) cytoplasm (Crebbp)
Anatomy Link Frequency
nucleus 1
Lung 1
Crebbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cva 18 99.82 Very High Very High Very High
Inflammation 261 97.96 Very High Very High Very High
ischemia 54 51.52 Quite High
cytokine 27 24.32 Low Low
Inflammatory response 18 5.00 Very Low Very Low Very Low
Restless leg syndrome 9 5.00 Very Low Very Low Very Low
ketamine 9 5.00 Very Low Very Low Very Low
chemokine 9 5.00 Very Low Very Low Very Low
withdrawal 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hemorrhage 27 99.82 Very High Very High Very High
Hemorrhagic Shock 207 99.18 Very High Very High Very High
INFLAMMATION 207 97.96 Very High Very High Very High
Pneumonia 63 82.84 Quite High
Shock 72 80.72 Quite High
Reperfusion Injury 36 75.36 Quite High
Cv Unclassified Under Development 54 51.52 Quite High
Lung Injury 36 21.04 Low Low
Injury 63 18.72 Low Low
Adult Respiratory Distress Syndrome 72 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interactions between CBP and CREB or p65 were demonstrated with a modification of the method reported by Gerritsen and coworkers.21 Lung nuclear extracts (10 ?
CBP Binding (Interactions) of in Lung
1) Confidence 0.16 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2898548 Disease Relevance 0 Pain Relevance 0
These data are supported by the findings of Shenkar et al., who similarly demonstrated that inhibition of xanthine oxidase and production of reactive oxygen species in mice before hemorrhage reduced interactions between p65 and CBP, while CREB-CBP associations were significantly increased.11
CBP Binding (associations) of associated with cva
2) Confidence 0.13 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2898548 Disease Relevance 0.51 Pain Relevance 0.25
Once in the nucleus, the p65 subunit is phosphorylated at serine 276, which enhances its ability to recruit CBP and p300 and subsequently bind to DNA.36,37 Here, HSPTX-resuscitated animals displayed a marked reduction in nuclear phosphorylated NF-?
CBP Binding (recruit) of in nucleus
3) Confidence 0.13 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2898548 Disease Relevance 0.36 Pain Relevance 0.11
B occurs through the same region of CBP (the KIX region), the competition between transcription factors for a finite amount of coactivator has the potential to be an additional transcription regulatory mechanism.21,39 In this study, the association between CBP and NF-?
CBP Binding (association) of
4) Confidence 0.13 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2898548 Disease Relevance 0.46 Pain Relevance 0.20
These data are supported by the findings of Shenkar et al., who similarly demonstrated that inhibition of xanthine oxidase and production of reactive oxygen species in mice before hemorrhage reduced interactions between p65 and CBP, while CREB-CBP associations were significantly increased.11
CBP Binding (interactions) of associated with cva
5) Confidence 0.13 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2898548 Disease Relevance 0.51 Pain Relevance 0.26
Resuscitation with HSPTX resulted in a marked rise in the association between CBP and CREB when compared with RL treatment (24% vs. 4.34%) (Figure 4).
CBP Binding (association) of
6) Confidence 0.13 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2898548 Disease Relevance 0.55 Pain Relevance 0.12
With HSPTX resuscitation, the association between CREB and CBP outweighs that demonstrated with NF-?
CBP Binding (association) of
7) Confidence 0.13 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2898548 Disease Relevance 0.58 Pain Relevance 0.14
Given that an increased association between CBP and CREB was evident with HSPTX, we sought to determine whether CREB-DNA binding was upregulated.
CBP Binding (association) of
8) Confidence 0.13 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2898548 Disease Relevance 0.61 Pain Relevance 0.14
To determine whether coactivator affinity for the transcription factors associated with inflammation was affected by the type of fluid administered after hemorrhagic shock, we evaluated the relative increases in CBP binding to NF-?
CBP Binding (binding) of associated with inflammation and hemorrhagic shock
9) Confidence 0.12 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2898548 Disease Relevance 0.62 Pain Relevance 0.12

General Comments

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