INT319725

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.12
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Crebbp) nucleus (Crebbp) DNA binding (Crebbp)
protein complex (Crebbp) transcription factor binding (Crebbp) cytoplasm (Crebbp)
Crebbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cva 4 98.92 Very High Very High Very High
Inflammation 58 93.40 High High
ischemia 12 51.52 Quite High
cytokine 6 24.32 Low Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Restless leg syndrome 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hemorrhage 6 98.92 Very High Very High Very High
INFLAMMATION 46 93.40 High High
Hemorrhagic Shock 46 90.92 High High
Pneumonia 14 61.96 Quite High
Shock 16 56.52 Quite High
Cv Unclassified Under Development 12 51.52 Quite High
Reperfusion Injury 8 51.16 Quite High
Injury 14 21.28 Low Low
Adult Respiratory Distress Syndrome 16 5.00 Very Low Very Low Very Low
Lung Injury 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data are supported by the findings of Shenkar et al., who similarly demonstrated that inhibition of xanthine oxidase and production of reactive oxygen species in mice before hemorrhage reduced interactions between p65 and CBP, while CREB-CBP associations were significantly increased.11
Positive_regulation (increased.11) of CBP Binding (associations) of associated with cva
1) Confidence 0.17 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2898548 Disease Relevance 0.51 Pain Relevance 0.26
Given that an increased association between CBP and CREB was evident with HSPTX, we sought to determine whether CREB-DNA binding was upregulated.
Positive_regulation (increased) of CBP Binding (association) of
2) Confidence 0.17 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2898548 Disease Relevance 0.61 Pain Relevance 0.14

General Comments

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