INT319729

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.88
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rela, Crebbp) DNA binding (Rela, Crebbp) protein complex (Rela, Crebbp)
transcription factor binding (Rela, Crebbp) cytoplasm (Rela, Crebbp) cell proliferation (Crebbp)
Anatomy Link Frequency
nucleus 1
Rela (Mus musculus)
Crebbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cva 4 99.82 Very High Very High Very High
Inflammation 58 89.24 High High
ischemia 12 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Restless leg syndrome 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hemorrhage 6 99.82 Very High Very High Very High
INFLAMMATION 46 89.24 High High
Hemorrhagic Shock 46 75.68 Quite High
Pneumonia 14 69.76 Quite High
Shock 16 62.08 Quite High
Lung Injury 8 24.04 Low Low
Injury 14 17.96 Low Low
Adult Respiratory Distress Syndrome 16 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 12 5.00 Very Low Very Low Very Low
Reperfusion Injury 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Once in the nucleus, the p65 subunit is phosphorylated at serine 276, which enhances its ability to recruit CBP and p300 and subsequently bind to DNA.36,37 Here, HSPTX-resuscitated animals displayed a marked reduction in nuclear phosphorylated NF-?
p65 Binding (bind) of CBP in nucleus
1) Confidence 0.02 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2898548 Disease Relevance 0.37 Pain Relevance 0.12
These data are supported by the findings of Shenkar et al., who similarly demonstrated that inhibition of xanthine oxidase and production of reactive oxygen species in mice before hemorrhage reduced interactions between p65 and CBP, while CREB-CBP associations were significantly increased.11
p65 Binding (interactions) of CBP associated with cva
2) Confidence 0.02 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2898548 Disease Relevance 0.51 Pain Relevance 0.26

General Comments

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