INT319758

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Context Info
Confidence 0.73
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.87
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Dcx) intracellular (Dcx) cytoplasm (Dcx)
Anatomy Link Frequency
neuronal 1
Dcx (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 19 98.36 Very High Very High Very High
Pyramidal cell 2 52.88 Quite High
cerebral cortex 4 50.92 Quite High
Cannabinoid receptor 2 50.00 Quite Low
Eae 12 5.44 Low Low
Cannabinoid 23 5.00 Very Low Very Low Very Low
antagonist 15 5.00 Very Low Very Low Very Low
Endocannabinoid 6 5.00 Very Low Very Low Very Low
cannabis 6 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 52 96.68 Very High Very High Very High
Neurodegenerative Disease 95 94.04 High High
Subacute Sclerosing Panencephalitis 1 73.76 Quite High
Parkinson's Disease 2 69.92 Quite High
Frontotemporal Dementia 2 69.24 Quite High
Supranuclear Palsy 1 68.04 Quite High
Disease 91 66.76 Quite High
Amyloid Plaque 15 64.36 Quite High
Dementia 7 30.40 Quite Low
Cognitive Disorder 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In these zones, phosphorylated tau was colocalized with doublecortin, a cytoskeletal protein that serves as a marker for neuronal migration, while tau knockout mice showed similar numbers of doublecortin-expressing cells but also a significant decrease in migration of these cells.
Localization (colocalized) of doublecortin in neuronal associated with targeted disruption
1) Confidence 0.73 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915753 Disease Relevance 0.87 Pain Relevance 0.10
The primary antibodies were applied in the following concentrations: BrdU (1:500, Harlan Seralab), anti-Doublecortin (DCX, 1:200, Santa Cruz Biotechnologies), anti-Calretinin (1:250, Santa Cruz), anti-GFP (to visualize Nestin, 1:500, Swant), anti-NeuN (1:100, Chemicon), anti-GFAP (1:250, Chemicon), anti-CB1 (1:250, LifeBioscience).
Localization (visualize) of Doublecortin
2) Confidence 0.32 Published 2010 Journal Cell Commun Signal Section Body Doc Link PMC2898685 Disease Relevance 0 Pain Relevance 0

General Comments

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