INT319780

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Context Info
Confidence 0.31
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.51
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Dio1) endoplasmic reticulum (Dio1)
Anatomy Link Frequency
poly 2
Dio1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 4 90.16 High High
cocaine 33 85.92 High High
antagonist 5 78.72 Quite High
Dopamine 6 78.28 Quite High
Inflammation 3 77.44 Quite High
Glutamate 1 50.00 Quite Low
Eae 15 27.28 Quite Low
imagery 3 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Glutamate receptor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 36 98.92 Very High Very High Very High
Cancer 55 98.88 Very High Very High Very High
Apoptosis 29 97.20 Very High Very High Very High
INFLAMMATION 3 77.44 Quite High
Disease 3 74.20 Quite High
Body Weight 5 55.20 Quite High
Skin Cancer 53 50.00 Quite Low
Neuroblastoma 47 50.00 Quite Low
Metastasis 4 41.28 Quite Low
Solid Tumor 3 24.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It suppresses the expression of cyclin D1, which is deregulated in several types of tumor, and it also induces apoptosis in tumor cells by activating caspase-8, which leads to cleavage of Bid, thus resulting in sequential release of mitochondrial cytochrome c and activation of caspase-9 and caspase-3, cleavage of poly ADP ribose polymerase (PARP) and apoptosis of tumor cells.
Negative_regulation (suppresses) of Gene_expression (expression) of D1 in poly associated with cancer and apoptosis
1) Confidence 0.31 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 1.04 Pain Relevance 0.08
We found that, like D1 deletion, mGluR5 deletion nearly abolished operant responding for sensory stimuli.
Negative_regulation (abolished) of Gene_expression (deletion) of D1
2) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994905 Disease Relevance 0.47 Pain Relevance 0.32

General Comments

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