INT31981

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Context Info
Confidence 0.44
First Reported 1985
Last Reported 1993
Negated 1
Speculated 1
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.03
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 2
neurons 2
Lhb (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 5 100.00 Very High Very High Very High
Morphine 6 99.64 Very High Very High Very High
narcan 11 95.08 Very High Very High Very High
Endogenous opioid 2 75.00 Quite High
opiate 3 65.52 Quite High
MU agonist 1 64.72 Quite High
Enkephalin 1 60.88 Quite High
Disease Link Frequency Relevance Heat
Polycystic Ovary Syndrome 3 99.60 Very High Very High Very High
Eating Disorder 5 99.56 Very High Very High Very High
Reprotox - General 1 2 75.60 Quite High
Weight Loss 2 75.16 Quite High
Aging 1 75.00 Quite High
Body Weight 1 72.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate whether changes in opioid tone play a role in the age-associated changes in LH release in men, the influence of an antiopioid, naltrexone, on plasma LH levels and LH pulses was studied in a group of young and elderly normal men.
Regulation (influence) of Regulation (pulses) of LH in plasma associated with opioid
1) Confidence 0.44 Published 1989 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2909555 Disease Relevance 0.07 Pain Relevance 0.10
Pretreatment with morphine or DADLE did not alter the LH response to GnRH (100 micrograms) stimulation, indicating a hypothalamic site of action for the opioid inhibition of LH release.
Neg (not) Regulation (alter) of Regulation (response) of LH associated with opioid and morphine
2) Confidence 0.17 Published 1985 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2981242 Disease Relevance 0 Pain Relevance 1.11
OBJECTIVE: To investigate the influence of opioid system on the exaggerated LH response to GnRH test in the polycystic ovarian syndrome (PCOS).
Spec (investigate) Regulation (influence) of Regulation (response) of LH associated with polycystic ovary syndrome and opioid
3) Confidence 0.16 Published 1993 Journal Fertil. Steril. Section Abstract Doc Link 8458488 Disease Relevance 0.27 Pain Relevance 0.10
Data could support the hypothesis of either a primitive impairment of LH-RH neurons, or an alteration in central regulation of LH-RH pulsar in anorexia nervosa.
Regulation (alteration) of Regulation (regulation) of LH-RH in neurons associated with eating disorder
4) Confidence 0.03 Published 1988 Journal Fertil. Steril. Section Abstract Doc Link 3129313 Disease Relevance 0.69 Pain Relevance 0.26

General Comments

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