INT31989

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Context Info
Confidence 0.47
First Reported 1989
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 43
Total Number 46
Disease Relevance 19.38
Pain Relevance 2.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SOD1) peroxisome (SOD1) protein complex (SOD1)
cytoplasm (SOD1) cytosol (SOD1) extracellular space (SOD1)
Anatomy Link Frequency
body 4
monocyte 1
muscle 1
skeletal muscle 1
band 1
SOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 312 98.72 Very High Very High Very High
Dynorphin 4 98.64 Very High Very High Very High
Multiple sclerosis 13 98.12 Very High Very High Very High
spinal inflammation 31 94.92 High High
withdrawal 31 92.40 High High
Osteoarthritis 51 89.84 High High
Glutamate 3 89.48 High High
cytokine 84 87.84 High High
chemokine 3 86.72 High High
Neuritis 16 83.08 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 401 100.00 Very High Very High Very High
Motor Neuron Diseases 158 100.00 Very High Very High Very High
Cognitive Disorder 40 100.00 Very High Very High Very High
Seronegative Spondarthritis 22 100.00 Very High Very High Very High
Fasciculation 2 99.48 Very High Very High Very High
Death 64 98.96 Very High Very High Very High
Paralysis 8 98.88 Very High Very High Very High
INFLAMMATION 336 98.72 Very High Very High Very High
Spasticity 2 98.44 Very High Very High Very High
Diabetes Complications 9 98.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A well-known example is that the RXR homodimer and several other RXR heterodimers can recognize and bind to the DR1 element [29].
homodimer Binding (recognize) of
1) Confidence 0.47 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0
Kaplan–Meier survival curves from patients with fALS-causing SOD1 mutations, non-SOD1-related fALS, and sALS were generated.
SOD1 Binding (generated) of
2) Confidence 0.37 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2486295 Disease Relevance 0.44 Pain Relevance 0
A cell wall component, peptidoglycan (PGN) of gram-positive bacteria is the preferred ligand of the TLR2 homodimer, and lipopolysaccharides (LPS) of gram-negative bacteria is recognized by TLR4 [4].
homodimer Binding (ligand) of
3) Confidence 0.36 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.11 Pain Relevance 0.09
Western blotting assay for Cu/Zn superoxide dismutase
Cu/Zn superoxide dismutase Binding (assay) of
4) Confidence 0.36 Published 2008 Journal BMC Physiol Section Body Doc Link PMC2443377 Disease Relevance 0.06 Pain Relevance 0
Here we show, in a human dendritic cell-like cell line and in human monocyte-derived dendritic cells, that the formation of HLA-B27 homodimers follows maturation and activatory stimuli.
homodimer Binding (formation) of in monocyte
5) Confidence 0.36 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575614 Disease Relevance 0.37 Pain Relevance 0.22
Recent studies suggest the formation of NCoA6(NRC) homodimers, which have been shown to occur using both yeast two-hybrid and in vitro binding assays [Mahajan and Samuels, 2000].
homodimer Binding (formation) of
6) Confidence 0.36 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
However, as SOD does not bind to cellular membranes and is rapidly excreted from the kidney, it has not been practically used so far [2].
SOD Neg (not) Binding (bind) of in kidney
7) Confidence 0.36 Published 2008 Journal Colorectal Disease Section Body Doc Link PMC2659364 Disease Relevance 0.31 Pain Relevance 0
Our findings imply that aggregation of unfolded SOD1 is toxic for ALS patients, and in fact accounts for 69% of the variability in mutant Cu/Zn-superoxide-dismutase-linked familial ALS patient survival times.



SOD1 Binding (aggregation) of associated with motor neuron diseases
8) Confidence 0.36 Published 2008 Journal PLoS Biology Section Abstract Doc Link PMC2486295 Disease Relevance 1.06 Pain Relevance 0.03
Relationship between the SOD2 Ala16Val (C/T) polymorphism and SOD activity in healthy subjects and patients with DM
SOD Binding (activity) of associated with diabetes mellitus
9) Confidence 0.36 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2386118 Disease Relevance 0.53 Pain Relevance 0
This analysis indicated that SOD1 and SOD2 genotypes are significantly associated with macroangiopathy.
SOD1 Binding (associated) of
10) Confidence 0.36 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2386118 Disease Relevance 0.95 Pain Relevance 0
The effect of the SOD1 +35A/C polymorphism on SOD activity in healthy subjects and diabetic patients with DM
SOD Binding (activity) of associated with diabetes mellitus
11) Confidence 0.36 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2386118 Disease Relevance 0.49 Pain Relevance 0
Association of the SOD1, SOD2 and CAT polymorphism, BMI, age, duration of diabetes, sex, type of diabetes and SOD activity as independent variables with the presence of microangiopathy or macroangiopathy as dependent variables was performed using a logistic regression model.
SOD Binding (Association) of associated with diabetes mellitus
12) Confidence 0.36 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2386118 Disease Relevance 0.85 Pain Relevance 0
The association of enzyme activity and polymorphisms in SOD1 and SOD2 with diabetes control and vascular complications of diabetes mellitus
SOD1 Binding (association) of associated with diabetes complications and diabetes mellitus
13) Confidence 0.36 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2386118 Disease Relevance 0.84 Pain Relevance 0
Association of the SOD1, SOD2 and CAT polymorphism, BMI, age, duration of diabetes, sex, type of diabetes and SOD activity as independent variables with the presence of microangiopathy or macroangiopathy as dependent variables was performed using a logistic regression model.
SOD1 Binding (Association) of associated with diabetes mellitus
14) Confidence 0.36 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2386118 Disease Relevance 0.82 Pain Relevance 0
This particular mutation was chosen, because it does not affect the activity of SOD1.
SOD1 Neg (not) Binding (activity) of
15) Confidence 0.35 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC2211486 Disease Relevance 1.46 Pain Relevance 0.21
These cell surface HLA-B27 homodimers can be recognised by NK receptors such as KIR3DL2 that do not recognise the monomeric form [11].
homodimer Binding (recognised) of
16) Confidence 0.35 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575614 Disease Relevance 0.55 Pain Relevance 0.18
The p50 homodimer, but not p65/c-Rel and NF-kappa B, bound specifically to a DNA-motif within the dynorphin A-encoding gene sequence.
homodimer Binding (bound) of associated with dynorphin
17) Confidence 0.35 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7968369 Disease Relevance 0.05 Pain Relevance 0.09
The dynorphin A-encoding sequence may represent an intragenic target for the p50 homodimer, which when bound to the sequence suppresses transcription.
homodimer Binding (bound) of associated with dynorphin
18) Confidence 0.35 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7968369 Disease Relevance 0 Pain Relevance 0.10
HLA B27 homodimer formation has also been demonstrated in certain cell lines in vivo, and preliminary data suggest that significant numbers of T cells from patients with spondyloarthropathy express a ligand for HLA B27 homodimers.
homodimer Binding (ligand) of in T cells associated with seronegative spondarthritis
19) Confidence 0.35 Published 2002 Journal Rheumatology (Oxford) Section Abstract Doc Link 12154202 Disease Relevance 1.15 Pain Relevance 0.14
A well-known example is that the RXR homodimer and several other RXR heterodimers can recognize and bind to the DR1 element [29].
homodimer Binding (bind) of
20) Confidence 0.35 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0

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