INT31990

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 1989
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 124
Total Number 126
Disease Relevance 67.79
Pain Relevance 12.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SOD1) peroxisome (SOD1) protein complex (SOD1)
cytoplasm (SOD1) cytosol (SOD1) extracellular space (SOD1)
Anatomy Link Frequency
blood 5
skin 4
liver 4
lens 3
dendritic cell 2
SOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 43 99.70 Very High Very High Very High
Inflammation 755 99.32 Very High Very High Very High
ischemia 40 99.20 Very High Very High Very High
Opioid 7 99.16 Very High Very High Very High
Bioavailability 40 99.04 Very High Very High Very High
Paracetamol 14 99.04 Very High Very High Very High
pulpitis 4 98.88 Very High Very High Very High
tolerance 106 98.64 Very High Very High Very High
Morphine 12 98.56 Very High Very High Very High
Bile 84 98.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 1336 100.00 Very High Very High Very High
Hypertension 392 100.00 Very High Very High Very High
Poisoning 34 100.00 Very High Very High Very High
Motor Neuron Diseases 305 99.96 Very High Very High Very High
Diabetes Mellitus 923 99.84 Very High Very High Very High
Injury 305 99.84 Very High Very High Very High
Gastroesophageal Reflux Disease 99 99.82 Very High Very High Very High
Targeted Disruption 208 99.64 Very High Very High Very High
Apoptosis 416 99.60 Very High Very High Very High
Stomach Cancer 58 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The severity of fALS thus is related to mutation-induced increases in SOD1 aggregation propensity.
Positive_regulation (increases) of SOD1
1) Confidence 0.69 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2486295 Disease Relevance 0.15 Pain Relevance 0.07
Transgenic flies expressing increased Cu/ZnSOD and catalase [22] displayed extended lifespan.
Positive_regulation (increased) of SOD associated with targeted disruption and lifespan
2) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2637430 Disease Relevance 1.16 Pain Relevance 0
Induction of HLA-B27 heavy chain-homodimers after dendritic cell stimulation
Positive_regulation (Induction) of homodimer in dendritic cell
3) Confidence 0.67 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575614 Disease Relevance 0.08 Pain Relevance 0
A dose-dependent increase in MDA levels and SOD activity was also observed, which indicated a link between oxidative stress and nephrotoxicity.
Positive_regulation (increase) of SOD associated with nephrotoxicity and stress
4) Confidence 0.65 Published 2001 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11440826 Disease Relevance 1.59 Pain Relevance 0.24
The results indicated that the increase in SOD activity in the inflammatory periodontal tissue is associated with oxidative stimulation in periodontitis patients [13].
Positive_regulation (increase) of SOD associated with periodontitis and inflammation
5) Confidence 0.60 Published 2010 Journal Journal of Periodontal & Implant Science Section Body Doc Link PMC2931304 Disease Relevance 0.81 Pain Relevance 0.10
SOD activity increases remarkably in irreversible pulpitis while it decreases significantly in the gingival tissue close to the deep periodontal pocket [6-8].
Positive_regulation (increases) of SOD associated with pulpitis and periodontal pocket
6) Confidence 0.60 Published 2010 Journal Journal of Periodontal & Implant Science Section Body Doc Link PMC2931304 Disease Relevance 0.68 Pain Relevance 0.25
Studies in patients with liver disease have shown that silymarin increases superoxide dismutase (SOD) activity of lymphocytes and erythrocytes, as well as the expression of SOD in lymphocytes.
Positive_regulation (increases) of SOD in lymphocytes associated with liver disease
7) Confidence 0.55 Published 2001 Journal BioDrugs Section Abstract Doc Link 11520257 Disease Relevance 0.24 Pain Relevance 0
We expanded upon these studies with a larger set of fALS-causing SOD1 mutations as well as larger patient cohorts.
Positive_regulation (causing) of SOD1
8) Confidence 0.50 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2486295 Disease Relevance 0.72 Pain Relevance 0
The Chiti–Dobson equation results for all fALS-causing SOD1 mutations with patients' survival data also were evaluated in a univariate Cox proportional hazard model (Table 3).
Positive_regulation (evaluated) of SOD1
9) Confidence 0.50 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2486295 Disease Relevance 0.45 Pain Relevance 0.09
However, a trend towards a significant group × time interaction (p = 0.06) was revealed with subsequent post-hoc analysis indicating that although SOD levels increased over time.
Positive_regulation (increased) of SOD
10) Confidence 0.47 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2315638 Disease Relevance 0.25 Pain Relevance 0
After SM administration GSH and AA significantly increase and SOD activity was significantly enhanced.
Positive_regulation (enhanced) of SOD
11) Confidence 0.46 Published 2007 Journal Phytomedicine Section Abstract Doc Link 16638633 Disease Relevance 0.25 Pain Relevance 0.54
HSA NP-transfected cells exhibited enhanced SOD1 activity that was 5 fold higher than untreated cells, indicating the overexpression of the functional gene.
Positive_regulation (enhanced) of SOD1
12) Confidence 0.46 Published 2007 Journal Molecular Vision Section Abstract Doc Link PMC2768759 Disease Relevance 0 Pain Relevance 0
Levels of Cu/Zn superoxide dismutase were increased in wound tissue from mice treated with 6, 8 dithio-UA compared to vehicle-treated mice, suggesting that the UA analog enhances endogenous cellular antioxidant defenses.
Positive_regulation (increased) of Cu/Zn superoxide dismutase associated with injury
13) Confidence 0.45 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2850366 Disease Relevance 0.94 Pain Relevance 0.03
R1-STAT1 complex seems to be internalized and translocated to the nucleus, where the activated STAT1 homodimer binds to DNA at GAS elements and induces the first wave of responses [204,207-211].
Positive_regulation (activated) of homodimer in nucleus
14) Confidence 0.45 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.06 Pain Relevance 0.11
Our previous work using a similar training stimulus indicated that this effect was due to a training induced induction of the anti-oxidant enzymes, catalase and Cu/Zn superoxide dismutase [61].
Positive_regulation (induction) of Cu/Zn superoxide dismutase
15) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994592 Disease Relevance 0.59 Pain Relevance 0.08
Serum SOD activity was higher in CC than in TT genotype of SOD2 gene (p < 0,05) and higher in AA than in CC genotype of SOD1 gene (p < 0,05).
Positive_regulation (higher) of SOD
16) Confidence 0.44 Published 2008 Journal BMC Med Genet Section Abstract Doc Link PMC2386118 Disease Relevance 0.74 Pain Relevance 0
Since 2000, a proprietary melon juice concentrate containing high level of SOD has been developed, its use as a dietary supplement has been a new subject of interest and its antioxidant and anti-inflammatory properties have been demonstrated [8].
Positive_regulation (level) of SOD associated with inflammation
17) Confidence 0.44 Published 2009 Journal Nutr J Section Body Doc Link PMC2757026 Disease Relevance 1.07 Pain Relevance 0.16
This HP was increased in SOD1-TG and its over-expression may lead or represent impaired cytoskeleton and/or mRNA splicing in hippocampus, which in turn may be in agreement with cytoskeleton and mRNA splicing deficits observed in DS brain [41,42].
Positive_regulation (increased) of SOD1 in hippocampus associated with down syndrome and hippocampus
18) Confidence 0.44 Published 2004 Journal Proteome Sci Section Body Doc Link PMC446209 Disease Relevance 0.09 Pain Relevance 0.05
An abnormal gall bladder ejection fraction could be an indication for cholecystectomy, while a fatty meal-stimulated bile duct dilatation mandates SOM and possible sphincterotomy.[47] Of the patients who have documented SOD and an intact gall bladder and who are treated with sphincterotomy, first, only 43% have long-term pain relief; some additional patients eventually show response to cholecystectomy.[48]
Positive_regulation (documented) of SOD in gall bladder associated with pain, bile and gallbladder disease
19) Confidence 0.43 Published 2008 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC2702883 Disease Relevance 0.65 Pain Relevance 0.31
The SOD activity was evaluated using an SOD Assay Kit - WST (Dojindo Laboratories, Kumamoto, Japan) according to the manufacturer's instruction, and an ELISA reader (Model-680®) at 450 nm.
Positive_regulation (evaluated) of SOD
20) Confidence 0.43 Published 2010 Journal Journal of Periodontal & Implant Science Section Body Doc Link PMC2931304 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox