INT31990

Context Info Confidence 0.69 First Reported 1989 Last Reported 2010 Negated 0 Speculated 2 Reported most in Body Documents 124 Total Number 126 Disease Relevance 67.79 Pain Relevance 12.52

mitochondrion (SOD1) peroxisome (SOD1) protein complex (SOD1) cytoplasm (SOD1) cytosol (SOD1) extracellular space (SOD1)

Anatomy Link Frequency blood 5 skin 4 liver 4 lens 3 dendritic cell 2 SOD1 (Homo sapiens)

Pain Link Frequency Relevance Heat Central nervous system 43 99.70 Inflammation 755 99.32 ischemia 40 99.20 Opioid 7 99.16 Bioavailability 40 99.04 Paracetamol 14 99.04 pulpitis 4 98.88 tolerance 106 98.64 Morphine 12 98.56 Bile 84 98.24

Disease Link Frequency Relevance Heat Stress 1336 100.00 Hypertension 392 100.00 Poisoning 34 100.00 Motor Neuron Diseases 305 99.96 Diabetes Mellitus 923 99.84 Injury 305 99.84 Gastroesophageal Reflux Disease 99 99.82 Targeted Disruption 208 99.64 Apoptosis 416 99.60 Stomach Cancer 58 99.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The severity of fALS thus is related to mutation-induced increases in SOD1 aggregation propensity.

Positive_regulation (increases) of SOD1

1) Confidence 0.69 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2486295 Disease Relevance 0.15 Pain Relevance 0.07

Transgenic flies expressing increased Cu/ZnSOD and catalase [22] displayed extended lifespan.

Positive_regulation (increased) of SOD associated with targeted disruption and lifespan

2) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2637430 Disease Relevance 1.16 Pain Relevance 0

Induction of HLA-B27 heavy chain-homodimers after dendritic cell stimulation

Positive_regulation (Induction) of homodimer in dendritic cell

3) Confidence 0.67 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575614 Disease Relevance 0.08 Pain Relevance 0

A dose-dependent increase in MDA levels and SOD activity was also observed, which indicated a link between oxidative stress and nephrotoxicity.

Positive_regulation (increase) of SOD associated with nephrotoxicity and stress

4) Confidence 0.65 Published 2001 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11440826 Disease Relevance 1.59 Pain Relevance 0.24

The results indicated that the increase in SOD activity in the inflammatory periodontal tissue is associated with oxidative stimulation in periodontitis patients [13].

Positive_regulation (increase) of SOD associated with periodontitis and inflammation

5) Confidence 0.60 Published 2010 Journal Journal of Periodontal & Implant Science Section Body Doc Link PMC2931304 Disease Relevance 0.81 Pain Relevance 0.10

SOD activity increases remarkably in irreversible pulpitis while it decreases significantly in the gingival tissue close to the deep periodontal pocket [6-8].

Positive_regulation (increases) of SOD associated with pulpitis and periodontal pocket

6) Confidence 0.60 Published 2010 Journal Journal of Periodontal & Implant Science Section Body Doc Link PMC2931304 Disease Relevance 0.68 Pain Relevance 0.25

Studies in patients with liver disease have shown that silymarin increases superoxide dismutase (SOD) activity of lymphocytes and erythrocytes, as well as the expression of SOD in lymphocytes.

Positive_regulation (increases) of SOD in lymphocytes associated with liver disease

7) Confidence 0.55 Published 2001 Journal BioDrugs Section Abstract Doc Link 11520257 Disease Relevance 0.24 Pain Relevance 0

We expanded upon these studies with a larger set of fALS-causing SOD1 mutations as well as larger patient cohorts.

Positive_regulation (causing) of SOD1

8) Confidence 0.50 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2486295 Disease Relevance 0.72 Pain Relevance 0

The Chiti–Dobson equation results for all fALS-causing SOD1 mutations with patients' survival data also were evaluated in a univariate Cox proportional hazard model (Table 3).

Positive_regulation (evaluated) of SOD1

9) Confidence 0.50 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2486295 Disease Relevance 0.45 Pain Relevance 0.09

However, a trend towards a significant group × time interaction (p = 0.06) was revealed with subsequent post-hoc analysis indicating that although SOD levels increased over time.

Positive_regulation (increased) of SOD

10) Confidence 0.47 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2315638 Disease Relevance 0.25 Pain Relevance 0

After SM administration GSH and AA significantly increase and SOD activity was significantly enhanced.

Positive_regulation (enhanced) of SOD

11) Confidence 0.46 Published 2007 Journal Phytomedicine Section Abstract Doc Link 16638633 Disease Relevance 0.25 Pain Relevance 0.54

HSA NP-transfected cells exhibited enhanced SOD1 activity that was 5 fold higher than untreated cells, indicating the overexpression of the functional gene.

Positive_regulation (enhanced) of SOD1

12) Confidence 0.46 Published 2007 Journal Molecular Vision Section Abstract Doc Link PMC2768759 Disease Relevance 0 Pain Relevance 0

Levels of Cu/Zn superoxide dismutase were increased in wound tissue from mice treated with 6, 8 dithio-UA compared to vehicle-treated mice, suggesting that the UA analog enhances endogenous cellular antioxidant defenses.

Positive_regulation (increased) of Cu/Zn superoxide dismutase associated with injury

13) Confidence 0.45 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2850366 Disease Relevance 0.94 Pain Relevance 0.03

R1-STAT1 complex seems to be internalized and translocated to the nucleus, where the activated STAT1 homodimer binds to DNA at GAS elements and induces the first wave of responses [204,207-211].

Positive_regulation (activated) of homodimer in nucleus

14) Confidence 0.45 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.06 Pain Relevance 0.11

Our previous work using a similar training stimulus indicated that this effect was due to a training induced induction of the anti-oxidant enzymes, catalase and Cu/Zn superoxide dismutase [61].

Positive_regulation (induction) of Cu/Zn superoxide dismutase

15) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994592 Disease Relevance 0.59 Pain Relevance 0.08

Serum SOD activity was higher in CC than in TT genotype of SOD2 gene (p < 0,05) and higher in AA than in CC genotype of SOD1 gene (p < 0,05).

Positive_regulation (higher) of SOD

16) Confidence 0.44 Published 2008 Journal BMC Med Genet Section Abstract Doc Link PMC2386118 Disease Relevance 0.74 Pain Relevance 0

Since 2000, a proprietary melon juice concentrate containing high level of SOD has been developed, its use as a dietary supplement has been a new subject of interest and its antioxidant and anti-inflammatory properties have been demonstrated [8].

Positive_regulation (level) of SOD associated with inflammation

17) Confidence 0.44 Published 2009 Journal Nutr J Section Body Doc Link PMC2757026 Disease Relevance 1.07 Pain Relevance 0.16

This HP was increased in SOD1-TG and its over-expression may lead or represent impaired cytoskeleton and/or mRNA splicing in hippocampus, which in turn may be in agreement with cytoskeleton and mRNA splicing deficits observed in DS brain [41,42].

Positive_regulation (increased) of SOD1 in hippocampus associated with down syndrome and hippocampus

18) Confidence 0.44 Published 2004 Journal Proteome Sci Section Body Doc Link PMC446209 Disease Relevance 0.09 Pain Relevance 0.05

An abnormal gall bladder ejection fraction could be an indication for cholecystectomy, while a fatty meal-stimulated bile duct dilatation mandates SOM and possible sphincterotomy.[47] Of the patients who have documented SOD and an intact gall bladder and who are treated with sphincterotomy, first, only 43% have long-term pain relief; some additional patients eventually show response to cholecystectomy.[48]

Positive_regulation (documented) of SOD in gall bladder associated with pain, bile and gallbladder disease

19) Confidence 0.43 Published 2008 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC2702883 Disease Relevance 0.65 Pain Relevance 0.31

The SOD activity was evaluated using an SOD Assay Kit - WST (Dojindo Laboratories, Kumamoto, Japan) according to the manufacturer's instruction, and an ELISA reader (Model-680®) at 450 nm.

Positive_regulation (evaluated) of SOD

20) Confidence 0.43 Published 2010 Journal Journal of Periodontal & Implant Science Section Body Doc Link PMC2931304 Disease Relevance 0 Pain Relevance 0

General Comments

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