INT31991

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Context Info
Confidence 0.75
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 33
Total Number 33
Disease Relevance 12.98
Pain Relevance 4.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (NTS) extracellular region (NTS)
Anatomy Link Frequency
CHO 4
plasma 1
pancreatic islet 1
cleavage 1
brainstem 1
NTS (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 19 100.00 Very High Very High Very High
Enkephalin 16 99.92 Very High Very High Very High
substance P 20 99.78 Very High Very High Very High
Chronic pancreatitis 12 99.58 Very High Very High Very High
Somatostatin 19 98.82 Very High Very High Very High
medulla 13 98.72 Very High Very High Very High
Cholecystokinin 3 98.42 Very High Very High Very High
Serotonin 8 97.84 Very High Very High Very High
antagonist 26 97.36 Very High Very High Very High
c fibre 4 96.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nash(non-alcoholic Steatohepatitis) 279 100.00 Very High Very High Very High
Infection 55 100.00 Very High Very High Very High
Pancreatic Cancer 28 99.84 Very High Very High Very High
Pancreatitis 12 99.58 Very High Very High Very High
Vomiting 131 97.72 Very High Very High Very High
Cancer 37 97.20 Very High Very High Very High
Body Weight 4 96.32 Very High Very High Very High
Syndrome 186 96.24 Very High Very High Very High
Aniridia 70 93.88 High High
Disease 71 93.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When CCK was administered during gastric distension, it significantly enhanced NTS Fos expression in response to distension in Cap rats.
Gene_expression (expression) of NTS
1) Confidence 0.75 Published 2005 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15905220 Disease Relevance 0 Pain Relevance 0.54
Lower levels of neurotensin were found in stage IV pancreatic cancer than in stages I-II (t = 1.82, P < 0.04) and in grade II than in grade I (t = 2.21, P < 0.02).
Gene_expression (levels) of neurotensin associated with pancreatic cancer
2) Confidence 0.60 Published 1996 Journal Tumori Section Abstract Doc Link 9061071 Disease Relevance 1.24 Pain Relevance 0.27
Significant correlations were found between serum levels of neurotensin and two indices of nutrition: albumin (r = 0.60, P < 0.05) and the percentage reduction in body weight (Z = 2.20, P < 0.02).
Gene_expression (levels) of neurotensin in body associated with body weight
3) Confidence 0.60 Published 1996 Journal Tumori Section Abstract Doc Link 9061071 Disease Relevance 1.20 Pain Relevance 0.25
The aim of this study was to evaluate the variations of serum levels of neurotensin in pancreatic cancer.
Gene_expression (levels) of neurotensin associated with pancreatic cancer
4) Confidence 0.60 Published 1996 Journal Tumori Section Abstract Doc Link 9061071 Disease Relevance 0.96 Pain Relevance 0.23
In the present study, we demonstrate that in Chinese hamster ovary (CHO) cells expressing the rat NTS2 receptor, neurotensin (NT), levocabastine, neuromedin N, and the high-affinity NT receptor antagonist SR48692 [2-[[1-(-7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carbonyl]amino]adamantane-2-carboxylic acid] all bind to and activate the NTS2 receptor.
Gene_expression (expressing) of NTS2 in CHO associated with antagonist
5) Confidence 0.59 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15361549 Disease Relevance 0 Pain Relevance 0.30
TT cells were found to produce some other hormones as well, namely ACTH, neurotensin, enkephalin, PTHrP, gastrin-releasing peptide (GRP), serotonin but also functional proteins of the chromogranin group, synaptophysin, NSE, calbindin and tyrosine hydroxylase.
Gene_expression (produce) of neurotensin associated with enkephalin and serotonin
6) Confidence 0.58 Published 1997 Journal Histol. Histopathol. Section Abstract Doc Link 9046062 Disease Relevance 0.16 Pain Relevance 0.20
The other NTS sources were blood (3 isolates) and urine (1 isolate).
Gene_expression (sources) of NTS in urine
7) Confidence 0.55 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693839 Disease Relevance 0.65 Pain Relevance 0.08
S. enteritidis was the most common isolate regardless of NTS source or isolation date (Fig. 3A), there was one predominant PFGE type, A0, and this profile was further differentiated into 2 subtypes (A0 and A1) with a 1-3-bands difference (F=0.8-1.0).
Gene_expression (source) of NTS in bands
8) Confidence 0.55 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693839 Disease Relevance 0.29 Pain Relevance 0
Although all our NTS isolates were susceptible to ciprofloxacin, 19.4% (7 of 36 isolates) and 46.8% (30 of 64 isolates) of the human and livestock NTS isolates were resistant to nalidixic acid (MIC ?
Gene_expression (isolates) of NTS
9) Confidence 0.55 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693839 Disease Relevance 0.14 Pain Relevance 0
Dendrogram analysis of XbaI-digested genomic DNA separated by PFGE showed that certain common, dominant PFGE groups are present among NTS from humans and broiler-chicken, namely, type A for S. enteritidis, type D for S. typhimurium.
Gene_expression (present) of NTS
10) Confidence 0.55 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693839 Disease Relevance 0.45 Pain Relevance 0
A total of 36 representative human NTS isolates were collected from patients with clinical NTS infections who visited Korea University Guro Hospital that was located in Southwestern area of Seoul, between October 2002 and August 2003.


Gene_expression (infections) of NTS associated with infection
11) Confidence 0.55 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693839 Disease Relevance 0.40 Pain Relevance 0
In the present study, we demonstrate that in Chinese hamster ovary (CHO) cells expressing the rat NTS2 receptor, neurotensin (NT), levocabastine, neuromedin N, and the high-affinity NT receptor antagonist SR48692 [2-[[1-(-7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carbonyl]amino]adamantane-2-carboxylic acid] all bind to and activate the NTS2 receptor.
Gene_expression (expressing) of neurotensin in CHO associated with antagonist
12) Confidence 0.53 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15361549 Disease Relevance 0 Pain Relevance 0.30
In chronic pancreatitis patients, the serum levels of neurotensin were correlated with serum amylase (r = 0.95, P < 0.01).
Gene_expression (levels) of neurotensin associated with chronic pancreatitis
13) Confidence 0.52 Published 1996 Journal Tumori Section Abstract Doc Link 9061071 Disease Relevance 1.19 Pain Relevance 0.28
We have previously shown that an in vivo administration of neurotensin (NT) stimulates contraction of dog gallbladder (GB), but produces dilatation of GB in humans.
Gene_expression (produces) of NT
14) Confidence 0.52 Published 1989 Journal Dig. Dis. Sci. Section Abstract Doc Link 2910678 Disease Relevance 0 Pain Relevance 0
We have previously shown that an in vivo administration of neurotensin (NT) stimulates contraction of dog gallbladder (GB), but produces dilatation of GB in humans.
Gene_expression (produces) of neurotensin
15) Confidence 0.52 Published 1989 Journal Dig. Dis. Sci. Section Abstract Doc Link 2910678 Disease Relevance 0 Pain Relevance 0
NTS2-induced activation of ERK1/2 was not species-specific, because the same agonistic effects of NT and analogs were observed in CHO cells transfected with the human NTS2 receptor.
Gene_expression (transfected) of NTS2 in CHO
16) Confidence 0.51 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15361549 Disease Relevance 0 Pain Relevance 0.07
In the present study, we demonstrate that in Chinese hamster ovary (CHO) cells expressing the rat NTS2 receptor, neurotensin (NT), levocabastine, neuromedin N, and the high-affinity NT receptor antagonist SR48692 [2-[[1-(-7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carbonyl]amino]adamantane-2-carboxylic acid] all bind to and activate the NTS2 receptor.
Gene_expression (expressing) of NT in CHO associated with antagonist
17) Confidence 0.46 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15361549 Disease Relevance 0 Pain Relevance 0.30
The optimum frequency of electrical stimulation to a peripheral nerve means that a pattern of excitation must be applied to sensory fibers of different diameters [146] and that this pattern must be detected in the dorsal NTS swallowing group in order to trigger specific interneurons to start the swallow [54, 91, 147].
Gene_expression (detected) of NTS in interneurons
18) Confidence 0.43 Published 2010 Journal Dysphagia Section Body Doc Link PMC2992653 Disease Relevance 0 Pain Relevance 0.03
In turn, NTS neurons transmit these messages to the brainstem, which directs emetic behavior (Hornby 2001).
Gene_expression (neurons) of NTS in brainstem associated with medulla and vomiting
19) Confidence 0.38 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503671 Disease Relevance 1.12 Pain Relevance 0.62
By contrast, the formation of the latter product was highly potentiated by dithiothreitol and inhibited by the endopeptidase 3.4.24.15 inhibitor Cpp-Ala-Ala-Tyr-pAB, two effects that were not observed for neurotensin(1-10) production.
Gene_expression (production) of neurotensin
20) Confidence 0.34 Published 1996 Journal Brain Res. Section Abstract Doc Link 8869556 Disease Relevance 0 Pain Relevance 0.08

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