INT319920

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Context Info
Confidence 0.29
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.31
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (SCN9A)
SCN9A (Homo sapiens)
Pain Link Frequency Relevance Heat
Nav1.7 49 100.00 Very High Very High Very High
dorsal root ganglion 27 100.00 Very High Very High Very High
hyperexcitability 10 100.00 Very High Very High Very High
addiction 14 84.96 Quite High
Paroxysmal extreme pain disorder 18 72.80 Quite High
sodium channel 12 36.88 Quite Low
Neuronal excitability 2 19.04 Low Low
Pain 19 5.00 Very Low Very Low Very Low
nav1.8 8 5.00 Very Low Very Low Very Low
Action potential 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 27 100.00 Very High Very High Very High
Somatoform Disorder 19 72.80 Quite High
Erythermalgia 18 72.44 Quite High
Disease 3 5.20 Low Low
Pain 16 5.00 Very Low Very Low Very Low
Neuropathic Pain 7 5.00 Very Low Very Low Very Low
Inflammatory Pain 4 5.00 Very Low Very Low Very Low
Congenital Pain Insensitivity 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Syndrome 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together with our results showing similar IC50 of ranolazine block of WT and mutant Nav1.7 peak currents, these data suggests that ranolazine may not have a preferential effect in blocking mutant Nav1.7-induced DRG hyperexcitability.
Negative_regulation (blocking) of Localization (hyperexcitability) of Nav1.7-induced associated with dorsal root ganglion, hyperexcitability and nav1.7
1) Confidence 0.29 Published 2010 Journal Mol Pain Section Body Doc Link PMC2898769 Disease Relevance 0.31 Pain Relevance 0.92

General Comments

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