INT31994

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Context Info
Confidence 0.41
First Reported 1989
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 5.54
Pain Relevance 2.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nbr1) lysosome (Nbr1) cytoplasm (Nbr1)
Anatomy Link Frequency
plasma cells 1
Nbr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 11 99.96 Very High Very High Very High
aspirin 8 99.66 Very High Very High Very High
endometriosis 8 98.56 Very High Very High Very High
dexamethasone 1 98.54 Very High Very High Very High
pain pelvic 4 97.08 Very High Very High Very High
Migraine 10 90.64 High High
monoamine 1 85.84 High High
Neuronal excitability 1 80.48 Quite High
Dismenorea 7 50.00 Quite Low
Disease Link Frequency Relevance Heat
Cancer 7 100.00 Very High Very High Very High
Pain 5 99.96 Very High Very High Very High
Proteinuria 3 99.82 Very High Very High Very High
Breast Cancer 10 99.60 Very High Very High Very High
Endometriosis (extended) 8 98.56 Very High Very High Very High
Disease Progression 1 98.24 Very High Very High Very High
Reprotox - General 3 4 97.08 Very High Very High Very High
Disease 5 96.44 Very High Very High Very High
Multiple Myeloma 3 92.84 High High
Nociception 8 91.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The authors conclude that determination of CA-125 levels may assist in the evaluation and treatment of women with chronic pelvic pain.
Negative_regulation (determination) of CA-125 associated with pain pelvic
1) Confidence 0.41 Published 1989 Journal Fertil. Steril. Section Abstract Doc Link 2910718 Disease Relevance 0.97 Pain Relevance 0.64
ASA and ZOL did not inhibit nBR responses in healthy subjects.
Negative_regulation (inhibit) of nBR associated with aspirin
2) Confidence 0.34 Published 2004 Journal Cephalalgia Section Abstract Doc Link 15265054 Disease Relevance 0.72 Pain Relevance 0.96
The serum CA125 levels reduced significantly starting from 6 months after device insertion (p<.001).
Negative_regulation (reduced) of CA125
3) Confidence 0.29 Published 2009 Journal Contraception Section Body Doc Link 19185671 Disease Relevance 0.12 Pain Relevance 0
The increased CA125 level is related to the degree of proteinuria and after prednisolone and cyclosporine therapy, proteinuria and the CA125 level gradually decreased.
Negative_regulation (decreased) of CA125 associated with proteinuria
4) Confidence 0.25 Published 2002 Journal Am. J. Nephrol. Section Abstract Doc Link 12169874 Disease Relevance 1.28 Pain Relevance 0.08
After treatment with cyclophosphamide and dexamethasone, the peripheral blood plasma cells disappeared and there was a dramatic decrease in the CA125 and CA15.3 tumor markers.
Negative_regulation (decrease) of CA125 in plasma cells associated with cancer and dexamethasone
5) Confidence 0.12 Published 2008 Journal Clinical lymphoma & myeloma Section Abstract Doc Link 18854288 Disease Relevance 0.80 Pain Relevance 0.12
We did not find vaccination significantly reduced serum tumor markers CA15-3, CEA and CA125 of these breast cancer patients.
Negative_regulation (reduced) of CA125 associated with cancer and breast cancer
6) Confidence 0.09 Published 2000 Journal Cancer Biother. Radiopharm. Section Abstract Doc Link 11155821 Disease Relevance 1.14 Pain Relevance 0.07
We found a significant decrease in nBR pain and reflex thresholds both 1 and 4 h post-NTG.
Negative_regulation (decrease) of nBR associated with pain
7) Confidence 0.01 Published 2009 Journal Pain Section Abstract Doc Link 19457613 Disease Relevance 0.50 Pain Relevance 0.41

General Comments

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