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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.47
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk12) cell cycle (Mapk12) kinase activity (Mapk12)
cytoplasm (Mapk12)
Anatomy Link Frequency
mast cells 1
Mapk12 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 7 96.72 Very High Very High Very High
Dorsal horn 4 83.92 Quite High
Inflammation 42 76.80 Quite High
painful pain 1 74.00 Quite High
qutenza 3 61.04 Quite High
Neuropathic pain 1 50.24 Quite High
Migraine 41 50.00 Quite Low
depression 4 40.80 Quite Low
Central nervous system 1 31.16 Quite Low
Peripheral sensitization 2 29.36 Quite Low
Disease Link Frequency Relevance Heat
Stress 1 100.00 Very High Very High Very High
Asthma 22 91.68 High High
Disease 12 88.52 High High
Cyst 1 83.52 Quite High
Cancer 1 83.36 Quite High
Pressure And Volume Under Development 2 83.16 Quite High
INFLAMMATION 42 76.80 Quite High
Rhinitis 5 73.68 Quite High
Pain 7 72.88 Quite High
Hypersensitivity 65 71.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To receive more insight into the mode of action, further research is required to explain the influence of beta-escin on intracellular signaling cascades in mast cells, such as mitogen- or stress-activated protein kinase pathways, on calcium influx and on transcription factors such as NF-?
Gene_expression (pathways) of stress-activated protein kinase in mast cells associated with stress
1) Confidence 0.08 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2898835 Disease Relevance 0.85 Pain Relevance 0.04
Moreover, in CNS, hypertonicity induces AQP-1 synthesis via extracellular signal-regulated kinases, p38 kinase, and c-Jun terminal kinase [44].
Gene_expression (synthesis) of p38 kinase
2) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 0.61 Pain Relevance 0.34

General Comments

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