INT320020

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 2.79
Pain Relevance 6.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
respiratory 1
Kcnn4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 473 99.78 Very High Very High Very High
ischemia 264 99.78 Very High Very High Very High
Opioid 33 98.40 Very High Very High Very High
opioid receptor 44 94.64 High High
agonist 22 76.64 Quite High
adenocard 11 75.72 Quite High
Angina 22 75.12 Quite High
MU agonist 22 64.00 Quite High
potassium channel 22 50.32 Quite High
Thoracotomy 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 253 99.78 Very High Very High Very High
Coronary Artery Disease 11 91.60 High High
Organ Transplantation 44 82.56 Quite High
Reperfusion Injury 33 80.64 Quite High
Stroke 22 75.76 Quite High
Cv General 3 Under Development 22 75.12 Quite High
Myocardial Infarction 22 73.76 Quite High
Ischemic Contracture 22 17.68 Low Low
Contracture 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a recent study, we could demonstrate that activation of mKCa channels not only reduced infarct size by preconditioning but also caused a significant reduction in the mitochondrial respiratory control index.13 Co-administration of the mKCa channel blocker, iberiotoxin, completely abolished the reduction in the respiratory control index, and we concluded that cardioprotection is mediated by activation of mKCa channels leading to mild mitochondrial uncoupling.
Positive_regulation (activation) of mKCa in respiratory
1) Confidence 0.01 Published 2010 Journal Can J Anaesth Section Body Doc Link PMC2899019 Disease Relevance 0.09 Pain Relevance 0.26
The mKCa channel blocker, paxilline, abolished both effects, confirming the findings of others that ischemic preconditioning involves activation of mKCa channels.
Positive_regulation (activation) of mKCa
2) Confidence 0.01 Published 2010 Journal Can J Anaesth Section Body Doc Link PMC2899019 Disease Relevance 0.10 Pain Relevance 0.36
We cannot rule out that morphine confers preconditioning via intracellular pathways leading to activation of mKCa channels.
Positive_regulation (activation) of mKCa associated with morphine
3) Confidence 0.01 Published 2010 Journal Can J Anaesth Section Body Doc Link PMC2899019 Disease Relevance 0.06 Pain Relevance 0.49
Besides ischemic preconditioning, our results demonstrate that pharmacological preconditioning with morphine also induces cardioprotection by activation of mKCa channels.
Positive_regulation (activation) of mKCa associated with morphine
4) Confidence 0.01 Published 2010 Journal Can J Anaesth Section Body Doc Link PMC2899019 Disease Relevance 0.20 Pain Relevance 0.29
The main finding of our study is that the opioid, morphine, initiates preconditioning in a similar manner as ischemia, i.e., by activation of mKCa channels.
Positive_regulation (activation) of mKCa associated with ischemia, opioid and morphine
5) Confidence 0.01 Published 2010 Journal Can J Anaesth Section Body Doc Link PMC2899019 Disease Relevance 0.89 Pain Relevance 0.83
Cardioprotection by morphine-induced preconditioning is mediated by activation of mKCa channels.



Positive_regulation (activation) of mKCa associated with morphine
6) Confidence 0.01 Published 2010 Journal Can J Anaesth Section Abstract Doc Link PMC2899019 Disease Relevance 0.12 Pain Relevance 0.51
In the present study we investigated whether morphine-induced preconditioning also involves activation of mKCa channels.


Positive_regulation (activation) of mKCa associated with morphine
7) Confidence 0.01 Published 2010 Journal Can J Anaesth Section Abstract Doc Link PMC2899019 Disease Relevance 0.17 Pain Relevance 0.49
Vice versa, inhibition of the mKCa channel with paxilline did not block protection induced by inhibition of the mPTP with cyclosporine A (CsA).8 Whether cardiac preconditioning by morphine is also mediated by regulation of the mPTP due to mKCa channel activation is yet unknown.
Positive_regulation (activation) of mKCa associated with morphine
8) Confidence 0.01 Published 2010 Journal Can J Anaesth Section Body Doc Link PMC2899019 Disease Relevance 0.08 Pain Relevance 0.43
Xi et al. could show that morphine prevents mPTP opening by inactivation of GSK3beta.34 Our results showing that morphine confers preconditioning through activation of mKCa channels and the fact that enzymes like PKA regulate mKCa channel activation suggest future directions for investigating the underlying mechanism of morphine-induced cardioprotection.
Positive_regulation (activation) of mKCa associated with morphine
9) Confidence 0.01 Published 2010 Journal Can J Anaesth Section Body Doc Link PMC2899019 Disease Relevance 0.50 Pain Relevance 0.98
However, the means by which morphine regulates mKCa channel activation to induce preconditioning is unknown.
Positive_regulation (activation) of mKCa associated with morphine
10) Confidence 0.01 Published 2010 Journal Can J Anaesth Section Body Doc Link PMC2899019 Disease Relevance 0.05 Pain Relevance 0.49
Xi et al. could show that morphine prevents mPTP opening by inactivation of GSK3beta.34 Our results showing that morphine confers preconditioning through activation of mKCa channels and the fact that enzymes like PKA regulate mKCa channel activation suggest future directions for investigating the underlying mechanism of morphine-induced cardioprotection.
Positive_regulation (activation) of mKCa associated with morphine
11) Confidence 0.01 Published 2010 Journal Can J Anaesth Section Body Doc Link PMC2899019 Disease Relevance 0.54 Pain Relevance 1.00

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