INT320070

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Context Info
Confidence 0.72
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.07
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (AVPR2) Golgi apparatus (AVPR2) endoplasmic reticulum (AVPR2)
plasma membrane (AVPR2) transmembrane transport (AVPR2) signal transducer activity (AVPR2)
Anatomy Link Frequency
kidney 2
AVPR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 40 79.52 Quite High
Central nervous system 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
beta blocker 2 5.00 Very Low Very Low Very Low
Demyelination 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyponatremia 128 95.64 Very High Very High Very High
Increased Venous Pressure Under Development 2 90.92 High High
Adrenal Insufficiency 4 55.92 Quite High
Thyroid Disease 4 55.00 Quite High
Diuresis 8 5.40 Low Low
Heart Rate Under Development 28 5.00 Very Low Very Low Very Low
Myocardial Infarction 28 5.00 Very Low Very Low Very Low
Cirrhosis 16 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 14 5.00 Very Low Very Low Very Low
Pressure Volume 2 Under Development 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The V2 receptor (V2R) is located primarily in the kidney, where it mediates antidiuresis.4 The major pharmacological effect of conivaptan in hyponatremia is accomplished by potent antagonism of V2R.
Localization (located) of V2R in kidney associated with hyponatremia
1) Confidence 0.72 Published 2010 Journal Core evidence Section Body Doc Link PMC2899773 Disease Relevance 0.53 Pain Relevance 0.08
The V2 receptor (V2R) is located primarily in the kidney, where it mediates antidiuresis.4 The major pharmacological effect of conivaptan in hyponatremia is accomplished by potent antagonism of V2R.
Localization (located) of V2 receptor in kidney associated with hyponatremia
2) Confidence 0.72 Published 2010 Journal Core evidence Section Body Doc Link PMC2899773 Disease Relevance 0.54 Pain Relevance 0.08

General Comments

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