INT320120

Context Info Confidence 0.04 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.09 Pain Relevance 0.82

mitochondrion (MTX1) enzyme binding (PTEN) lipid metabolic process (PTEN) cytoplasm (PTEN) cytosol (PTEN) cell proliferation (PTEN)

MTX1 (Homo sapiens) PTEN (Homo sapiens)

Pain Link Frequency Relevance Heat methotrexate 53 100.00 antagonist 11 90.24 rheumatoid arthritis 54 87.44 Etanercept 4 81.52 Adalimumab 5 78.80 Infliximab 7 75.84 spinal inflammation 31 50.00 Inflammation 19 16.68 Arthritis 34 5.00 psoriasis 5 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 54 87.44 Low Back Pain 33 50.00 Disease 18 40.24 INFLAMMATION 16 16.68 Seronegative Spondarthritis 31 5.00 Latent Tuberculosis 6 5.00 Infection 6 5.00 Psoriasis 6 5.00 Anaemia 5 5.00 Arthritis 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Although the additional benefit of adding GLM to MTX in this patient population was modest, it was similar to that which has been observed in previous studies of other TNF-?

MTX Positive_regulation (adding) of GLM associated with methotrexate

1) Confidence 0.04 Published 2010 Journal Core evidence Section Body Doc Link PMC2899784 Disease Relevance 0.09 Pain Relevance 0.82

General Comments

This test has worked.