INT320121

Context Info Confidence 0.05 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.76 Pain Relevance 0.49

plasma membrane (PTEN, TNF) intracellular (TNF) extracellular matrix organization (TNF) enzyme binding (PTEN) lipid metabolic process (PTEN) cytoplasm (PTEN)

PTEN (Homo sapiens) TNF (Homo sapiens)

Pain Link Frequency Relevance Heat Infliximab 14 96.40 Arthritis 68 74.48 psoriasis 10 73.36 Inflammation 38 62.72 spinal inflammation 62 59.84 rheumatoid arthritis 108 59.32 methotrexate 106 5.00 antagonist 22 5.00 Adalimumab 10 5.00 Etanercept 8 5.00

Disease Link Frequency Relevance Heat Arthritis 8 74.48 Psoriasis 12 73.36 Targeted Disruption 4 70.80 Low Back Pain 66 59.84 Seronegative Spondarthritis 62 59.52 Rheumatoid Arthritis 108 59.32 Disease 36 57.12 INFLAMMATION 32 5.00 Latent Tuberculosis 12 5.00 Infection 12 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

GLM demonstrated high affinity for both soluble (17 pM) and transmembrane TNF-?

GLM Binding (affinity) of TNF

1) Confidence 0.05 Published 2010 Journal Core evidence Section Body Doc Link PMC2899784 Disease Relevance 0.52 Pain Relevance 0.28

In preclinical studies, the affinity of GLM for soluble TNF-?

GLM Binding (affinity) of TNF

2) Confidence 0.05 Published 2010 Journal Core evidence Section Body Doc Link PMC2899784 Disease Relevance 0.25 Pain Relevance 0.21

General Comments

This test has worked.