INT320152

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Context Info
Confidence 0.23
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.59
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6, IL1RN) extracellular region (IL6, IL1RN) aging (IL6)
plasma membrane (IL1RN) nucleus (IL1RN) intracellular (IL1RN)
Anatomy Link Frequency
plasma 1
IL6 (Homo sapiens)
IL1RN (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 1 99.72 Very High Very High Very High
Arthritis 70 99.20 Very High Very High Very High
cytokine 22 96.48 Very High Very High Very High
Inflammation 8 96.08 Very High Very High Very High
visual analogue scale 2 30.08 Quite Low
rheumatoid arthritis 15 5.00 Very Low Very Low Very Low
chemokine 10 5.00 Very Low Very Low Very Low
corticosteroid 8 5.00 Very Low Very Low Very Low
methotrexate 6 5.00 Very Low Very Low Very Low
withdrawal 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 37 99.74 Very High Very High Very High
INFLAMMATION 10 99.32 Very High Very High Very High
Juvenile Chronic Polyarthritis 63 99.20 Very High Very High Very High
Anaemia 2 98.36 Very High Very High Very High
Thrombosis Related Under Development 2 97.98 Very High Very High Very High
Fever 9 90.16 High High
Influenza Virus Infection 15 88.28 High High
Critical Illness 37 81.60 Quite High
Necrosis 2 79.92 Quite High
Cancer 2 79.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL6 is known to be responsible for regulating plasma levels of IL1RA and IL10 [16].
IL6 Positive_regulation (responsible) of IL1RA in plasma
1) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 1.11 Pain Relevance 0.35
The high levels of IL-6, also being responsible for the impaired growth, thrombocytosis and chronic anemia, lead to the suggestion that systemic JIA is a IL-6-mediated disease.14 IL-6 and IL-1RA, being induced by IL-6, correlates with systemic JIA disease activity, which is not the case for IL-1 and TNF?.
IL-6 Positive_regulation (induced) of IL-1RA associated with anaemia, disease, thrombosis related under development and arthritis
2) Confidence 0.01 Published 2010 Journal Core evidence Section Body Doc Link PMC2899792 Disease Relevance 1.49 Pain Relevance 0.31

General Comments

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