INT320171

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.87
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MOCS1) small molecule metabolic process (MOCS1) nucleus (MOCS1)
MOCS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 54 62.72 Quite High
addiction 17 58.36 Quite High
headache 4 58.08 Quite High
Neurotransmitter 1 55.96 Quite High
Angina 1 44.72 Quite Low
Opioid 18 37.32 Quite Low
antagonist 6 36.12 Quite Low
sSRI 1 25.24 Quite Low
gABA 4 15.64 Low Low
Glutamate 3 15.16 Low Low
Disease Link Frequency Relevance Heat
Lysosome Storage Disease 6 84.24 Quite High
Fabry Disease 28 65.36 Quite High
Headache 4 58.88 Quite High
Alcohol Addiction 17 58.36 Quite High
Increased Venous Pressure Under Development 2 57.28 Quite High
Dizziness 4 56.48 Quite High
Vomiting 10 55.60 Quite High
Pressure Volume 2 Under Development 3 52.88 Quite High
Heart Rate Under Development 6 51.84 Quite High
Dyspnea 1 50.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This results in an increased amount of GLA in the lysosomes, as the enhancement of mutant enzyme expression could proportionally increase protein trafficking to the lysosome [29].
Positive_regulation (enhancement) of Gene_expression (expression) of enzyme
1) Confidence 0.01 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2995157 Disease Relevance 0.27 Pain Relevance 0
Disulfiram irreversibly inhibits aldehyde dehydrogenase (the enzyme that converts the relatively toxic metabolite acetaldehyde to the benign metabolite acetate); which is necessary for the metabolism of ethanol.[4] Ingestion of a single dose begins to affect ethanol metabolism within 1 to 2 hours; its peak effects are seen at 12 hours and its sustained effects (usually 12-72 hours) depend on the rate of new enzyme synthesis.
Positive_regulation (depend) of Gene_expression (synthesis) of enzyme
2) Confidence 0.01 Published 2007 Journal Indian Journal of Psychiatry Section Body Doc Link PMC2899994 Disease Relevance 0.60 Pain Relevance 0.25

General Comments

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