INT320260

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Context Info
Confidence 0.15
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.36
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Atf4, Creb1) DNA binding (Atf4, Creb1) nucleoplasm (Creb1)
mitochondrion (Creb1) nucleolus (Creb1) plasma membrane (Atf4)
Anatomy Link Frequency
spinal cord 1
Atf4 (Rattus norvegicus)
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 31 96.48 Very High Very High Very High
ischemia 1 75.36 Quite High
Neurotransmitter 5 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
GABAergic 3 5.00 Very Low Very Low Very Low
nMDA receptor 2 5.00 Very Low Very Low Very Low
Dopamine 2 5.00 Very Low Very Low Very Low
dopamine receptor 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 66 96.72 Very High Very High Very High
Cv Unclassified Under Development 1 75.36 Quite High
Repression 3 57.84 Quite High
Spinal Cord Injury 19 5.00 Very Low Very Low Very Low
Spasticity 18 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Paralysis 2 5.00 Very Low Very Low Very Low
Nervous System Malformation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ATF3 and ATF4 both belong to the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors and they have both been associated with trauma relating to the spinal cord.
ATF4 Binding (binding) of CREB in spinal cord associated with injury and spinal cord
1) Confidence 0.15 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.36 Pain Relevance 0.17

General Comments

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