INT32039

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Context Info
Confidence 0.37
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.92
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CPE) protein modification process (CPE) extracellular region (CPE)
Golgi apparatus (CPE) plasma membrane (CPE) nucleus (CPE)
Anatomy Link Frequency
plasma 1
L929 1
Hep-2 1
lung 1
CPE (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 4 99.88 Very High Very High Very High
opioid receptor 5 98.96 Very High Very High Very High
Opioid 6 98.12 Very High Very High Very High
Endogenous opioid 2 89.64 High High
bradykinin 1 87.52 High High
Dynorphin 1 84.44 Quite High
Morphine 2 84.32 Quite High
Pain 9 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 120 98.28 Very High Very High Very High
Lung Cancer 4 96.54 Very High Very High Very High
Disease 33 91.16 High High
Sprains And Strains 51 85.92 High High
Encephalopathy 6 71.56 Quite High
Togavirus Infection 69 61.52 Quite High
Reprotox - General 1 3 20.72 Low Low
Viral Meningitis 12 15.32 Low Low
Hepatitis 3 14.64 Low Low
Lymphopenia 3 12.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the enzyme shares some properties with other carboxypeptidase B-like enzymes, it is structurally, catalytically, and immunologically distinct from pancreatic carboxypeptidase A or B, human plasma carboxypeptidase N, and carboxypeptidase H ("enkephalin convertase").
Positive_regulation (pancreatic) of carboxypeptidase H in plasma associated with enkephalin
1) Confidence 0.37 Published 1989 Journal J. Biol. Chem. Section Abstract Doc Link 2914904 Disease Relevance 0 Pain Relevance 0.45
Tissue samples from patients with lung cancer were examined by immunohistochemistry to identify the components of the opioid network: beta-endorphin (END); its precursor, proopiomelanocortin (POMC); the key processing enzymes prohormone convertase 1 and 2; carboxypeptidase E; and END's corresponding opioid receptor, the mu-opioid receptor (MOR).
Positive_regulation (enzymes) of carboxypeptidase E in lung associated with lung cancer, opioid receptor and opioid
2) Confidence 0.20 Published 2010 Journal Pharmacol Rep Section Abstract Doc Link 20360624 Disease Relevance 0.26 Pain Relevance 0.86
Prior studies from the 1960s to 1980s have demonstrated that CHIKV replicates in various nonhuman cell lines, including Vero cells, chick embryo fibroblast–like cells, BHK21, L929, and Hep-2 cells [22–25], inducing generally a significant cytopathic effect (CPE) [2].
Positive_regulation (inducing) of CPE in L929
3) Confidence 0.05 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1904475 Disease Relevance 0.42 Pain Relevance 0
Viral titers of C6/36 supernatants were measured using a standard procedure (infection of Vero cells with serial dilutions of supernatants to be tested, and measure of the appearance of a CPE) [27] and were confirmed with a focus immunoassay (see Materials and Methods).
Positive_regulation (appearance) of CPE associated with infection
4) Confidence 0.05 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1904475 Disease Relevance 0.82 Pain Relevance 0
Prior studies from the 1960s to 1980s have demonstrated that CHIKV replicates in various nonhuman cell lines, including Vero cells, chick embryo fibroblast–like cells, BHK21, L929, and Hep-2 cells [22–25], inducing generally a significant cytopathic effect (CPE) [2].
Positive_regulation (inducing) of CPE in Hep-2
5) Confidence 0.02 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1904475 Disease Relevance 0.42 Pain Relevance 0

General Comments

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