INT32040

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Context Info
Confidence 0.35
First Reported 1988
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.67
Pain Relevance 1.53

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enzyme regulator activity (CPN2) extracellular region (CPN2)
Anatomy Link Frequency
plasma 3
hypothalamus 1
pituitary gland 1
CPN2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 11 98.84 Very High Very High Very High
bradykinin 3 87.52 High High
Dynorphin 2 84.44 Quite High
Neuropeptide 6 75.76 Quite High
Pain 4 75.00 Quite High
Potency 3 5.00 Very Low Very Low Very Low
Lasting pain 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 6 99.08 Very High Very High Very High
Pain 3 75.00 Quite High
Sprains And Strains 5 5.00 Very Low Very Low Very Low
Hemolysis 3 5.00 Very Low Very Low Very Low
Coagulation Disorder 1 5.00 Very Low Very Low Very Low
Bacterial Respiratory Disease 1 5.00 Very Low Very Low Very Low
Wound Healing 1 5.00 Very Low Very Low Very Low
Fungal Infection 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The seminal plasma carboxypeptidase did not cross-react with antiserum to human plasma carboxypeptidase N; other properties distinguish it from the blood plasma enzyme as well as from pancreatic carboxypeptidase B and granular, acid carboxypeptidase H (enkephalin convertase).
Positive_regulation (pancreatic) of carboxypeptidase in plasma associated with enkephalin
1) Confidence 0.35 Published 1988 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 3214176 Disease Relevance 0 Pain Relevance 0.32
Activity of carboxypeptidase N [correction of H] increased under emotional-algic stress in the rat pituitary gland and hypothalamus.
Positive_regulation (increased) of carboxypeptidase N in hypothalamus associated with stress
2) Confidence 0.30 Published 1994 Journal Fiziol Zh Im I M Sechenova Section Abstract Doc Link 7527703 Disease Relevance 0.34 Pain Relevance 0.15
Although the enzyme shares some properties with other carboxypeptidase B-like enzymes, it is structurally, catalytically, and immunologically distinct from pancreatic carboxypeptidase A or B, human plasma carboxypeptidase N, and carboxypeptidase H ("enkephalin convertase").
Positive_regulation (pancreatic) of carboxypeptidase in plasma associated with enkephalin
3) Confidence 0.17 Published 1989 Journal J. Biol. Chem. Section Abstract Doc Link 2914904 Disease Relevance 0 Pain Relevance 0.45
Although the enzyme shares some properties with other carboxypeptidase B-like enzymes, it is structurally, catalytically, and immunologically distinct from pancreatic carboxypeptidase A or B, human plasma carboxypeptidase N, and carboxypeptidase H ("enkephalin convertase").
Positive_regulation (pancreatic) of carboxypeptidase in plasma associated with enkephalin
4) Confidence 0.17 Published 1989 Journal J. Biol. Chem. Section Abstract Doc Link 2914904 Disease Relevance 0 Pain Relevance 0.45
Activity of carboxypeptidase N [correction of H] increased under emotional-algic stress in the rat pituitary gland and hypothalamus.
Positive_regulation (increased) of carboxypeptidase N in pituitary gland associated with stress
5) Confidence 0.10 Published 1994 Journal Fiziol Zh Im I M Sechenova Section Abstract Doc Link 7527703 Disease Relevance 0.34 Pain Relevance 0.15
The same fragments are recovered in the peptides that also have amidated C-termini, which indicates that the loss of the last two or three residues is not due to carboxypeptidase activity.
Neg (not) Positive_regulation (due) of carboxypeptidase
6) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937036 Disease Relevance 0 Pain Relevance 0

General Comments

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