INT320415

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 1.18
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Psmb10) cell morphogenesis (Psmb10) nucleus (Psmb10)
cytoplasm (Psmb10)
Anatomy Link Frequency
neuronal 2
neurons 2
Psmb10 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 16 86.64 High High
Glutamate receptor 64 80.40 Quite High
tetrodotoxin 40 71.76 Quite High
nMDA receptor 16 70.80 Quite High
Action potential 16 62.44 Quite High
potassium channel 8 16.44 Low Low
agonist 8 5.00 Very Low Very Low Very Low
Glutamate 8 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 16 99.40 Very High Very High Very High
Parkinson's Disease 16 99.26 Very High Very High Very High
Neurodegenerative Disease 32 98.00 Very High Very High Very High
Depression 16 86.64 High High
Aids-related Complex 8 82.88 Quite High
Dementia 32 77.48 Quite High
Frontotemporal Dementia 8 66.76 Quite High
Disease 24 64.08 Quite High
Intellectual Impairment 24 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The affinity purification methods used here should greatly facilitate such studies of 26S proteasome function in neurodegenerative disorders, studies of how neuronal activity regulates 26S proteasome properties, or the reported progressive decline of proteasome activity with aging (Dahlmann, 2007; Tonoki et al., 2009).
Negative_regulation (decline) of proteasome in neuronal associated with aging and neurodegenerative disease
1) Confidence 0.00 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2901091 Disease Relevance 0.66 Pain Relevance 0.03
It is also noteworthy that we could not detect by mass spectrometry parkin (an E3 mutated in autosomal-recessive juvenile Parkinsonism) and PI31 (which may function as an inhibitor of the 20S proteasome), which have been reported to interact with proteasomes in non-neuronal cells (McCutchen-Maloney et al., 2000; Sakata et al., 2003).
Negative_regulation (inhibitor) of proteasome in neuronal associated with parkinson's disease
2) Confidence 0.00 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2901091 Disease Relevance 0.10 Pain Relevance 0
Following the exposure of neurons to NMDA, we observed a long-lasting reduction in 26S proteasome activity assayed with fluorogenic peptide substrates (Figures 6A,B).
Negative_regulation (reduction) of proteasome in neurons
3) Confidence 0.00 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2901091 Disease Relevance 0.09 Pain Relevance 0.08
Proteasome inhibitors including MG132 and epoxomicin?
Negative_regulation (inhibitors) of Proteasome
4) Confidence 0.00 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2901091 Disease Relevance 0 Pain Relevance 0.24
In fact, the inhibition of proteasome activity can impair synaptic plasticity (Fonseca et al., 2006; Hou et al., 2006; Karpova et al., 2006), and certain types of learning in animals (Lopez-Salon et al., 2001; Lee et al., 2008).
Negative_regulation (inhibition) of proteasome
5) Confidence 0.00 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2901091 Disease Relevance 0.19 Pain Relevance 0
The loss of specific ligases from the proteasome may potentially decrease proteasome activity and alter substrate specificity (Kraut et al., 2007).
Negative_regulation (decrease) of proteasome
6) Confidence 0.00 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2901091 Disease Relevance 0.08 Pain Relevance 0.08
The similar decrease in 26S proteasome activity and ubiquitin-conjugate levels 4?
Negative_regulation (decrease) of proteasome
7) Confidence 0.00 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2901091 Disease Relevance 0.06 Pain Relevance 0.13
One possible interpretation is that neurons reduce 26S proteasome levels when there are fewer substrates to degrade.
Negative_regulation (reduce) of proteasome in neurons
8) Confidence 0.00 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2901091 Disease Relevance 0 Pain Relevance 0

General Comments

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