INT32042

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Context Info
Confidence 0.79
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0
Pain Relevance 2.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
adrenal medulla 1
embryonic kidney 1


Pain Term Frequency Confidence Heat
Morphine 13 100.00 Very High Very High Very High
Enkephalin 7 100.00 Very High Very High Very High
opioid receptor 9 100.00 Very High Very High Very High
MU agonist 2 99.30 Very High Very High Very High
medulla 2 98.36 Very High Very High Very High
Opioid 2 96.48 Very High Very High Very High
potassium channel 3 93.60 High High
cytokine 1 82.36 Quite High
agonist 2 75.00 Quite High
Kinase C 6 43.44 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ability of two opioid agonists, [d-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin (DAMGO) and morphine, to induce mu-opioid receptor (MOR) phosphorylation, desensitization, and internalization was examined in human embryonic kidney (HEK) 293 cells expressing rat MOR1 as well G protein-coupled inwardly rectifying potassium channel (GIRK) channel subunits.
Phosphorylation (phosphorylation) of enkephalin in embryonic kidney associated with mu agonist, potassium channel, opioid receptor, enkephalin and morphine
1) Confidence 0.79 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16682505 Disease Relevance 0 Pain Relevance 0.94
[D-Ser(2), Leu(5), Thr(6)]-enkephalin-exposure of HEK293 cells, expressing stably the delta-opioid receptor (delta-OR), leads to receptor-dependent STAT5B tyrosine phosphorylation and transcriptional activation.
Phosphorylation (phosphorylation) of enkephalin associated with opioid receptor and enkephalin
2) Confidence 0.79 Published 2010 Journal Neuropharmacology Section Abstract Doc Link 20433855 Disease Relevance 0 Pain Relevance 0.44
The isolation and chemical characterization of phosphorylated enkephalin-containing peptides from bovine adrenal medulla.
Phosphorylation (phosphorylated) of enkephalin in adrenal medulla associated with medulla and enkephalin
3) Confidence 0.61 Published 1989 Journal J. Biol. Chem. Section Title Doc Link 2914943 Disease Relevance 0 Pain Relevance 0.57
The method was applied for purification of seven synthetic enkephalin-related phosphorylated peptides.
Phosphorylation (phosphorylated) of enkephalin associated with enkephalin
4) Confidence 0.61 Published 1999 Journal Anal. Biochem. Section Abstract Doc Link 10328759 Disease Relevance 0 Pain Relevance 0.10

General Comments

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