INT320422

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.11
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Psmb10) cell morphogenesis (Psmb10) nucleus (Psmb10)
cytoplasm (Psmb10)
Anatomy Link Frequency
neurons 2
neuronal 1
Psmb10 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 40 97.72 Very High Very High Very High
agonist 5 96.96 Very High Very High Very High
tetrodotoxin 25 5.00 Very Low Very Low Very Low
nMDA receptor 10 5.00 Very Low Very Low Very Low
depression 10 5.00 Very Low Very Low Very Low
Action potential 10 5.00 Very Low Very Low Very Low
potassium channel 5 5.00 Very Low Very Low Very Low
Glutamate 5 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 20 99.30 Very High Very High Very High
Aging 10 96.92 Very High Very High Very High
Disease 15 86.24 High High
Dementia 20 80.08 Quite High
Frontotemporal Dementia 5 69.36 Quite High
Parkinson's Disease 10 66.92 Quite High
Intellectual Impairment 15 5.00 Very Low Very Low Very Low
Depression 10 5.00 Very Low Very Low Very Low
Aids-related Complex 5 5.00 Very Low Very Low Very Low
Targeted Disruption 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The affinity purification methods used here should greatly facilitate such studies of 26S proteasome function in neurodegenerative disorders, studies of how neuronal activity regulates 26S proteasome properties, or the reported progressive decline of proteasome activity with aging (Dahlmann, 2007; Tonoki et al., 2009).
Regulation (regulates) of proteasome in neuronal associated with aging and neurodegenerative disease
1) Confidence 0.00 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2901091 Disease Relevance 0.68 Pain Relevance 0.03
It is also likely that proteasome regulation occurs through changes in the levels of proteasome-interacting proteins.
Spec (likely) Regulation (regulation) of proteasome
2) Confidence 0.00 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2901091 Disease Relevance 0 Pain Relevance 0.05
There is growing evidence that ubiquitylation is not the only site of regulation of this pathway and that proteasome composition, and presumably function, can be regulated in multiple ways (Glickman and Raveh, 2005; Schmidt et al., 2005).
Regulation (regulated) of proteasome
3) Confidence 0.00 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2901091 Disease Relevance 0.25 Pain Relevance 0
Several studies have shown that neuron-specific mechanisms of 26S proteasome regulation may underlie synaptic plasticity (DiAntonio and Hicke, 2004; Bingol and Schuman, 2005; Yi and Ehlers, 2007).
Regulation (regulation) of proteasome in neuron
4) Confidence 0.00 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2901091 Disease Relevance 0.18 Pain Relevance 0.04
To investigate the interplay between proteasome regulation and synaptic plasticity, we exposed cultured neurons to glutamate receptor agonist NMDA.
Spec (investigate) Regulation (regulation) of proteasome in neurons associated with glutamate receptor and agonist
5) Confidence 0.00 Published 2010 Journal Frontiers in Molecular Neuroscience Section Abstract Doc Link PMC2901091 Disease Relevance 0 Pain Relevance 0.10

General Comments

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