INT320436

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Context Info
Confidence 0.21
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.42
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ube3a) protein modification process (Ube3a) nucleus (Ube3a)
intracellular (Ube3a) molecular_function (Ube3a) cellular_component (Ube3a)
Anatomy Link Frequency
neurons 2
Ube3a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 8 84.00 Quite High
tetrodotoxin 5 5.00 Very Low Very Low Very Low
nMDA receptor 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Action potential 2 5.00 Very Low Very Low Very Low
potassium channel 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Intellectual Impairment 3 91.76 High High
Targeted Disruption 1 80.96 Quite High
Angelman Syndrome 1 79.24 Quite High
Neurodegenerative Disease 4 50.00 Quite Low
Ataxia 1 47.84 Quite Low
Dementia 4 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Parkinson's Disease 2 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, UBE3A and HUWE1 dissociate from 26S proteasomes and become degraded after neurons are exposed to NMDA.
Positive_regulation (exposed) of Protein_catabolism (degraded) of UBE3A in neurons
1) Confidence 0.21 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2901091 Disease Relevance 0.42 Pain Relevance 0.04

General Comments

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