INT320451

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.21
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (BDNF) cytoplasmic membrane-bounded vesicle (BDNF)
Anatomy Link Frequency
hippocampus 2
ECT (Homo sapiens)
BDNF (Homo sapiens)
Pain Link Frequency Relevance Heat
antidepressant 58 100.00 Very High Very High Very High
Hippocampus 7 99.68 Very High Very High Very High
depression 58 92.46 High High
Neurotransmitter 11 71.12 Quite High
monoamine 13 45.84 Quite Low
Serotonin 8 34.08 Quite Low
deep brain stimulation 26 5.00 Very Low Very Low Very Low
Transcranial magnetic stimulation 22 5.00 Very Low Very Low Very Low
sSRI 11 5.00 Very Low Very Low Very Low
Inflammation 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 85 100.00 Very High Very High Very High
Neurodegenerative Disease 8 95.04 Very High Very High Very High
Death 4 94.64 High High
Frailty 2 93.94 High High
Depressive Disorder 49 88.56 High High
Stress 7 69.64 Quite High
Traumatic Stress Disorders 1 38.20 Quite Low
Anxiety Disorder 1 36.76 Quite Low
Neurological Disease 4 35.76 Quite Low
INFLAMMATION 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Key observations leading to and strengthening this theory are: (1) neurotrophic factors, especially BDNF and VEGF, are under-expressed in limbic structures implicated in depression (especially the hippocampus) and may contribute to their observed atrophy and increased sensitivity to death (Sapolsky, 2000; Duman and Monteggia, 2006); (2) HPA-axis dysfunction exacerbates this phenomenon, while effective antidepressant treatments counteract it by enhancing hippocampal BDNF mRNA expression through the cAMP-CREB cascade (Duman et al., 1997, 2000); and (3) ECT and MAOI antidepressants, considered to be the most effective at relieving depressive symptoms, were shown to most significantly increase BDNF and trkB (the BDNF receptor) mRNA expression in the hippocampus (Nibuya et al., 1995).


ECT Positive_regulation (increase) of Gene_expression (expression) of BDNF in hippocampus associated with antidepressant, depression, frailty, hippocampus and death
1) Confidence 0.05 Published 2010 Journal Frontiers in Neuroengineering Section Body Doc Link PMC2901135 Disease Relevance 1.21 Pain Relevance 0.49

General Comments

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