INT32052

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Context Info
Confidence 0.24
First Reported 1989
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.73
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Acot1) mitochondrion (Acot1) lipid metabolic process (Acot1)
cytoplasm (Acot1)
Anatomy Link Frequency
hippocampus 2
Acot1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neurotransmitter 6 100.00 Very High Very High Very High
Hippocampus 3 99.80 Very High Very High Very High
Intracerebroventricular 1 98.68 Very High Very High Very High
noradrenaline 9 83.68 Quite High
Clonidine 4 75.00 Quite High
cerebral cortex 8 12.72 Low Low
Pyramidal cell 6 5.00 Very Low Very Low Very Low
Bile 4 5.00 Very Low Very Low Very Low
Endogenous opioid 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 11 98.72 Very High Very High Very High
Liver Failure 10 98.48 Very High Very High Very High
Liver Disease 8 89.20 High High
Targeted Disruption 1 75.68 Quite High
Hyperammonemia 4 68.72 Quite High
Hepatic Encephalopathy 17 63.20 Quite High
Aggression 1 29.92 Quite Low
Sleep Disorders 1 25.00 Low Low
Cirrhosis 19 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intracerebroventricular injection of ethylcholine aziridinium (AF64A) (2 nmol/ventricle) induced a considerable decrease in the level of acetylcholine (ACh) in hippocampus (from 21.14 +/- 0.84 to 10.04 +/- 0.59 pmol/mg of tissue; p less than 0.001) 4 days after application.
Positive_regulation (induced) of Negative_regulation (decrease) of ACh in hippocampus associated with hippocampus and intracerebroventricular
1) Confidence 0.24 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2918312 Disease Relevance 0 Pain Relevance 0.36
In the animal model, increased AChE leads to a pronounced decrease in the levels of the neurotransmitter ACh which plays a critical role in cognitive function.
Positive_regulation (leads) of Negative_regulation (decrease) of ACh associated with cognitive disorder and neurotransmitter
2) Confidence 0.06 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0.73 Pain Relevance 0.05

General Comments

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