INT32053

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Context Info
Confidence 0.45
First Reported 1989
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 3.40
Pain Relevance 4.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tnc) extracellular region (Tnc) proteinaceous extracellular matrix (Tnc)
molecular_function (Tnc)
Anatomy Link Frequency
neurons 9
TNC 2
trigeminal nerve 2
microglia 1
Tnc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 5 100.00 Very High Very High Very High
Calcitonin gene-related peptide 105 99.84 Very High Very High Very High
Neuropeptide 15 97.76 Very High Very High Very High
fifth nerve 5 97.52 Very High Very High Very High
superficial lamina 1 97.28 Very High Very High Very High
Inflammation 70 95.36 Very High Very High Very High
Opioid 10 94.44 High High
trigeminal ganglion 30 91.04 High High
Snapping jaw 80 90.56 High High
central sensitization 70 90.40 High High
Disease Link Frequency Relevance Heat
Nociception 78 100.00 Very High Very High Very High
INFLAMMATION 115 95.36 Very High Very High Very High
Ganglion Cysts 30 91.04 High High
Temporomandibular Joint Syndrome 65 90.56 High High
Pain 51 82.12 Quite High
Cognitive Disorder 10 75.84 Quite High
Heart Rate Under Development 6 74.44 Quite High
Headache 4 72.76 Quite High
Asthma 1 68.92 Quite High
Epilepsy 1 57.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with L-KYN (300 mg/kg bw, i.p.) together with PROB (200 mg/kg bw, i.p.) and KYNA derivative (300 mg/kg bw, i.p.) attenuated the NTG-induced nNOS expression in the rat TNC.
Positive_regulation (-) of Gene_expression (expression) of TNC in TNC
1) Confidence 0.45 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19580819 Disease Relevance 0.21 Pain Relevance 0.32
When increasing amounts of the tail were immersed in a 50 degrees C waterbath, TNC neurons increased their discharges within a restricted range of tail surface areas (0.9-5.7 cm2); further increases in the stimulated surface size were not followed by increases in firing rate.
Positive_regulation (increased) of Gene_expression (neurons) of TNC in neurons
2) Confidence 0.44 Published 1989 Journal J. Neurophysiol. Section Abstract Doc Link 2918361 Disease Relevance 0.25 Pain Relevance 0.15
Saharan dust-containing atmospheric conditions induced c-fos expression in nociceptive neurons within TNC.
Positive_regulation (induced) of Gene_expression (expression) of TNC in neurons associated with nociception
3) Confidence 0.37 Published 2009 Journal Cephalalgia Section Abstract Doc Link 19735534 Disease Relevance 0.23 Pain Relevance 0.11
However, octreotide did not alter the average capsaicin-induced Fos expression in the TNC I-II and capsaicin sensitive behaviours were not modified by octreotide pretreatment.
Neg (not) Positive_regulation (capsaicin-induced) of Gene_expression (expression) of TNC I-II associated with qutenza
4) Confidence 0.29 Published 2000 Journal Cephalalgia Section Abstract Doc Link 10961767 Disease Relevance 0.22 Pain Relevance 0.52
Another interesting finding from our study was that dietary GSE decreases basal expression of the MAP kinase-responsive gene CGRP, while increasing expression of GLAST in the TNC.
Positive_regulation (increasing) of Gene_expression (expression) of TNC associated with calcitonin gene-related peptide
5) Confidence 0.17 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0.99 Pain Relevance 0.92
In our study, we observed increased expression of P-p38 in trigeminal ganglia neurons, and neurons and microglia in the TNC in response to CFA injection.
Positive_regulation (increased) of Gene_expression (expression) of TNC in neurons
6) Confidence 0.17 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0.42 Pain Relevance 0.66
Thus, increased expression of MKP-1 in trigeminal ganglia and the TNC would function to control MAP kinase activity in response to trigeminal nerve activation.
Positive_regulation (increased) of Gene_expression (expression) of TNC in trigeminal nerve associated with fifth nerve
7) Confidence 0.16 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0.22 Pain Relevance 0.13
In our study, we observed increased expression of P-p38 in trigeminal ganglia neurons, and neurons and microglia in the TNC in response to CFA injection.
Positive_regulation (increased) of in microglia Gene_expression (expression) of TNC in neurons
8) Confidence 0.06 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0.42 Pain Relevance 0.66
In our study, we observed increased expression of P-p38 in trigeminal ganglia neurons, and neurons and microglia in the TNC in response to CFA injection.
Positive_regulation (increased) of Gene_expression (expression) of TNC in neurons
9) Confidence 0.06 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0.42 Pain Relevance 0.66

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