INT32054

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Context Info
Confidence 0.59
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 25
Disease Relevance 9.36
Pain Relevance 12.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tnc) extracellular region (Tnc) proteinaceous extracellular matrix (Tnc)
molecular_function (Tnc)
Anatomy Link Frequency
neurons 6
TNC 3
trigeminal ganglia 3
dorsal horn 1
trigeminal nerve 1
Tnc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 102 100.00 Very High Very High Very High
trigeminal ganglion 87 100.00 Very High Very High Very High
chemokine 2 100.00 Very High Very High Very High
Calcitonin gene-related peptide 261 99.84 Very High Very High Very High
Migraine 210 99.84 Very High Very High Very High
neuropeptide release 1 99.82 Very High Very High Very High
qutenza 17 99.80 Very High Very High Very High
spinal dorsal horn 3 99.80 Very High Very High Very High
Spinal cord 100 99.68 Very High Very High Very High
Dorsal horn 12 99.30 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 190 100.00 Very High Very High Very High
Ganglion Cysts 87 100.00 Very High Very High Very High
Migraine Disorders 198 99.84 Very High Very High Very High
INFLAMMATION 288 95.36 Very High Very High Very High
Pain 182 94.48 High High
Temporomandibular Joint Syndrome 156 91.08 High High
Headache 110 87.84 High High
Migraine With Aura 6 87.12 High High
Hyperalgesia 16 87.04 High High
Neurogenic Inflammation 6 87.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At longer survivals (52 hr), labeled cells were present in lamina I of both the TNC and spinal dorsal horn.
Gene_expression (present) of TNC in spinal associated with spinal dorsal horn
1) Confidence 0.59 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9133395 Disease Relevance 0.47 Pain Relevance 0.45
When increasing amounts of the tail were immersed in a 50 degrees C waterbath, TNC neurons increased their discharges within a restricted range of tail surface areas (0.9-5.7 cm2); further increases in the stimulated surface size were not followed by increases in firing rate.
Gene_expression (neurons) of TNC in neurons
2) Confidence 0.59 Published 1989 Journal J. Neurophysiol. Section Abstract Doc Link 2918361 Disease Relevance 0.25 Pain Relevance 0.15
We also confirmed the eccentric-induced expression of six transcripts by quantitative RT-PCR (cardiac ankyrin-repeated protein, chemokine ligand 2, CCAAT/enhancer binding protein delta, IL-1 receptor, tenascin C, and cysteine-rich angiogenic inducer 61).
Gene_expression (expression) of tenascin C associated with chemokine
3) Confidence 0.58 Published 2003 Journal J. Appl. Physiol. Section Abstract Doc Link 12937035 Disease Relevance 0.09 Pain Relevance 0.17
Freely moving rats incubated within simulated atmospheric conditions containing (i) Saharan dust, (ii) Co(60) gamma ray-treated Saharan dust (sterilized) and (iii) dust-free air, were investigated for the presence of c-fos expression in trigeminal nucleus caudalis (TNC) and for NOx (nitrate+nitrite) levels in blood samples.
Gene_expression (expression) of TNC in blood
4) Confidence 0.54 Published 2009 Journal Cephalalgia Section Abstract Doc Link 19735534 Disease Relevance 0.16 Pain Relevance 0.04
Pretreatment with L-KYN (300 mg/kg bw, i.p.) together with PROB (200 mg/kg bw, i.p.) and KYNA derivative (300 mg/kg bw, i.p.) attenuated the NTG-induced nNOS expression in the rat TNC.
Gene_expression (expression) of TNC in TNC
5) Confidence 0.51 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19580819 Disease Relevance 0.21 Pain Relevance 0.31
Since NMDA receptors play a crucial role in trigeminal pain processing, the aim of our experiments was to compare the effects of L-kynurenine (L-KYN) combined with probenecid (PROB) or with 2-(2-N,N-dimethylaminoethylamine-1-carbonyl)-1H-quinolin-4-one hydrochloride alone, a newly synthetized KYNA derivative, on the NTG-induced nNOS expression in the rat TNC.
Gene_expression (expression) of TNC in TNC associated with pain and nmda receptor
6) Confidence 0.51 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19580819 Disease Relevance 0.24 Pain Relevance 0.32
In conclusion, we found both BK(Ca) channel mRNA and protein expression in the TG and the TNC.
Gene_expression (expression) of TNC associated with trigeminal ganglion
7) Confidence 0.48 Published 2010 Journal Neuroscience Section Abstract Doc Link 20211697 Disease Relevance 1.14 Pain Relevance 0.97
Saharan dust-containing atmospheric conditions induced c-fos expression in nociceptive neurons within TNC.
Gene_expression (expression) of TNC in neurons associated with nociception
8) Confidence 0.48 Published 2009 Journal Cephalalgia Section Abstract Doc Link 19735534 Disease Relevance 0.23 Pain Relevance 0.11
Neuropeptide release and the expression of c-fos like immunoreactivity (c-fos LI) within trigeminal nucleus caudalis neurons (TNC) are activation markers of the trigeminal nerve system.
Gene_expression (expression) of TNC in neurons associated with fifth nerve and neuropeptide release
9) Confidence 0.42 Published 2005 Journal Cephalalgia Section Abstract Doc Link 15689199 Disease Relevance 0.09 Pain Relevance 0.35
However, octreotide did not alter the average capsaicin-induced Fos expression in the TNC I-II and capsaicin sensitive behaviours were not modified by octreotide pretreatment.
Gene_expression (expression) of TNC I-II associated with qutenza
10) Confidence 0.39 Published 2000 Journal Cephalalgia Section Abstract Doc Link 10961767 Disease Relevance 0.22 Pain Relevance 0.52
Fos expression in the outer layers of the trigeminal nucleus caudalis (TNC I-II) and behavioural analysis were used to measure the effects of octreotide on capsaicin-induced trigeminovascular activation.
Gene_expression (expression) of TNC I-II in nucleus associated with qutenza
11) Confidence 0.35 Published 2000 Journal Cephalalgia Section Abstract Doc Link 10961767 Disease Relevance 0.25 Pain Relevance 0.50
Importantly, we found that the stimulatory effects of CFA on P-p38 expression in trigeminal ganglia and TNC were significantly repressed in animals receiving GSE.
Gene_expression (expression) of TNC in trigeminal ganglia
12) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0.57 Pain Relevance 0.53
The effect of GSE on basal MKP-1 expression in the TNC was similar to that observed in trigeminal ganglia.
Gene_expression (expression) of TNC in trigeminal ganglia
13) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0 Pain Relevance 0.32
In unstimulated control animals, CGRP staining was readily detected in neurons located in discrete bands within the dorsal horn of the spinal cord, including the TNC region.
Gene_expression (region) of TNC in dorsal horn associated with dorsal horn, spinal cord and calcitonin gene-related peptide
14) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0 Pain Relevance 0.32
A similar stimulatory effect was seen in the expression of the glial cell glutamate uptake transporter, GLAST, in the TNC of animals on a GSE supplemented diet.
Gene_expression (expression) of TNC in glial cell associated with glutamate
15) Confidence 0.23 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0 Pain Relevance 0.27
In our study, we observed increased expression of P-p38 in trigeminal ganglia neurons, and neurons and microglia in the TNC in response to CFA injection.
Gene_expression (expression) of TNC in neurons
16) Confidence 0.23 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0.42 Pain Relevance 0.66
GSE regulation of CGRP, MKP-1, and GLAST expression in the TNC
Gene_expression (expression) of TNC associated with calcitonin gene-related peptide
17) Confidence 0.23 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0 Pain Relevance 0.28
Minimal expression of P-p38 was detected in neurons and glia within the TNC obtained from control animals (Figure 6A).
Gene_expression (detected) of TNC in neurons
18) Confidence 0.23 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0.16 Pain Relevance 0.19
Another interesting finding from our study was that dietary GSE decreases basal expression of the MAP kinase-responsive gene CGRP, while increasing expression of GLAST in the TNC.
Gene_expression (expression) of TNC associated with calcitonin gene-related peptide
19) Confidence 0.23 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0.98 Pain Relevance 0.92
Thus, increased expression of MKP-1 in trigeminal ganglia and the TNC would function to control MAP kinase activity in response to trigeminal nerve activation.
Gene_expression (expression) of TNC in trigeminal nerve associated with fifth nerve
20) Confidence 0.21 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0.22 Pain Relevance 0.13

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