INT32057

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Context Info
Confidence 0.48
First Reported 1983
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 0.26
Pain Relevance 3.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Nln) mitochondrion (Nln) cytoplasm (Nln)
Anatomy Link Frequency
muscle 1
Nln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 22 99.32 Very High Very High Very High
Spinal cord 2 98.36 Very High Very High Very High
isoflurane 6 97.16 Very High Very High Very High
epidural 3 94.96 High High
analgesia 4 94.24 High High
Morphine 3 90.56 High High
lidocaine 1 89.68 High High
ketamine 6 88.52 High High
Analgesic 1 79.92 Quite High
Transcranial magnetic stimulation 3 72.88 Quite High
Disease Link Frequency Relevance Heat
Post-head Injury Coma 1 80.60 Quite High
Depression 1 65.84 Quite High
Pain 1 59.92 Quite High
Paresis 1 56.32 Quite High
Myalgia 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We described 2 patients who had developed significant decrease in MEP during the insertion of iliosacral screws for reconstruction of pelvic fractures.
Negative_regulation (decrease) of MEP
1) Confidence 0.48 Published 2000 Journal Masui Section Abstract Doc Link 10846383 Disease Relevance 0.06 Pain Relevance 0.13
After application of nembutal, MEP and H-response decreased in amplitude, eventually disappearing.
Negative_regulation (decreased) of MEP
2) Confidence 0.38 Published 1998 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 9755843 Disease Relevance 0.07 Pain Relevance 0.60
A similar reduction of MEP amplitudes was observed in 6 volunteers during breathing of an oxygen/nitrous oxide mixture (34%/66%), whereas fentanyl, flunitrazepam, and thiopental had only a minor effect on MEP.
Negative_regulation (reduction) of MEP
3) Confidence 0.35 Published 1989 Journal Neurosurgery Section Abstract Doc Link 2918976 Disease Relevance 0.08 Pain Relevance 0.28
Propofol and thiopental showed significantly stronger suppression of MEP, when compared to etomidate (both P < 0.01) and to methohexital (P = 0.01 and 0.05, respectively).
Negative_regulation (suppression) of MEP
4) Confidence 0.35 Published 1993 Journal Neurosurgery Section Abstract Doc Link 8413871 Disease Relevance 0 Pain Relevance 0.28
A dose-related reduction of the MEP amplitudes was seen in all drug groups, while the latencies remained constant.
Negative_regulation (reduction) of MEP
5) Confidence 0.35 Published 1993 Journal Neurosurgery Section Abstract Doc Link 8413871 Disease Relevance 0 Pain Relevance 0.29
Reduction of the amplitude was occasionally so prominent that the MEP was completely abolished before adequate anesthesia was achieved.
Negative_regulation (abolished) of MEP associated with anesthesia
6) Confidence 0.35 Published 1993 Journal Neurosurgery Section Abstract Doc Link 8413871 Disease Relevance 0 Pain Relevance 0.31
With train pulse stimulation, MEPs were recorded in 100% and 90% of animals at small and large doses of xenon, respectively, and a reduction in MEP amplitudes by xenon was more prominent than by propofol but less than isoflurane at large doses.
Negative_regulation (reduction) of MEP associated with isoflurane
7) Confidence 0.35 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16717315 Disease Relevance 0 Pain Relevance 0.41
Although no significant effect was noted on the SSEPs (amplitude or latency) or the MEP duration, there was a decrease in the MEP amplitude.
Negative_regulation (decrease) of MEP
8) Confidence 0.27 Published 2008 Journal Paediatr Anaesth Section Body Doc Link 18717802 Disease Relevance 0 Pain Relevance 0
VC, FEV1, MEP and MIP markedly decreased following laparotomy.
Negative_regulation (decreased) of MEP
9) Confidence 0.08 Published 1983 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 6687651 Disease Relevance 0 Pain Relevance 0.92
In the FCR muscle, the MEP inhibition was observed during the peak-pain, while a significant reduction of the H-reflex's amplitude was observed starting 1 min after the peak-pain.
Negative_regulation (inhibition) of MEP in muscle
10) Confidence 0.04 Published 2001 Journal Clin Neurophysiol Section Body Doc Link 11514246 Disease Relevance 0.06 Pain Relevance 0

General Comments

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