INT320583

Context Info Confidence 0.35 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.93 Pain Relevance 0.64

aging (Slc32a1)

Anatomy Link Frequency brain 1 Slc32a1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat ischemia 78 99.98 GABAergic 90 97.40 Neurotransmitter 5 96.40 gABA 39 93.44 Substantia nigra 73 92.84 interneuron 2 44.20 Dopamine 19 5.00 imagery 10 5.00 Enkephalin 9 5.00 substance P 9 5.00

Disease Link Frequency Relevance Heat Brain Hemorrhage 6 99.98 Cv Unclassified Under Development 72 91.80 Generalized Anxiety Disorder 13 87.24 Middle Cerebral Artery Infarction 3 56.56 Death 1 47.60 Injury 18 6.40 Parkinson's Disease 16 5.00 Apoptosis 13 5.00 Hypoxia 11 5.00 Disease 10 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Recent studies reported that focal brain ischemia decreases VGAT in the injured brain regions during the 72 hours after reperfusion [40].

Negative_regulation (decreases) of VGAT in brain associated with brain hemorrhage and ischemia

1) Confidence 0.35 Published 2010 Journal Cardiovascular Psychiatry and Neurology Section Body Doc Link PMC2957857 Disease Relevance 0.93 Pain Relevance 0.56

Furthermore, in double labeling experiments, 46.7±6.3% (SEM) of the gephyrin clusters and 39.0±6.2% (SEM) of the Homer1c clusters were opposed to VIAAT- and vGlut1-positive terminals, respectively.

Negative_regulation (opposed) of VIAAT

2) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2901346 Disease Relevance 0 Pain Relevance 0.08

General Comments

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