INT3206

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Context Info
Confidence 0.69
First Reported 1978
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 39
Total Number 39
Disease Relevance 19.36
Pain Relevance 17.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Got1) biosynthetic process (Got1) cellular amino acid metabolic process (Got1)
lysosome (Got1) cytoplasm (Got1)
Anatomy Link Frequency
liver 11
plasma 4
blood 1
brain 1
Got1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 14 100.00 Very High Very High Very High
Paracetamol 194 99.88 Very High Very High Very High
methotrexate 16 99.50 Very High Very High Very High
Analgesic 10 99.36 Very High Very High Very High
aspirin 13 98.88 Very High Very High Very High
cocaine 6 98.72 Very High Very High Very High
abdominal pain 1 98.18 Very High Very High Very High
chemokine 3 95.24 Very High Very High Very High
cytokine 7 94.16 High High
Potency 105 89.72 High High
Disease Link Frequency Relevance Heat
Death 18 100.00 Very High Very High Very High
Hyperbilirubinemia 1 99.96 Very High Very High Very High
Leukopenia 1 99.92 Very High Very High Very High
Apoptosis 47 99.90 Very High Very High Very High
Diarrhoea 5 99.90 Very High Very High Very High
Vomiting 14 99.70 Very High Very High Very High
Hepatotoxicity 141 99.68 Very High Very High Very High
Fatty Liver 2 99.56 Very High Very High Very High
Asthenia 8 99.50 Very High Very High Very High
Hepatomegaly 1 99.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AOM treatment led to hepatic damage, significant increase in plasma transaminase activity, decreased hepatic glutathione levels, and brain GSH/GSSG ratios as well as selective increases in expression of plasma proinflammatory cytokines.
Positive_regulation (increase) of plasma transaminase in brain associated with cytokine
1) Confidence 0.69 Published 2010 Journal Metab Brain Dis Section Abstract Doc Link 20198438 Disease Relevance 1.37 Pain Relevance 0.26
If, additionally, methotrexate is applied, there is an increase in the death rate, as well as in glutamate-oxaloacetate transaminase (GOT) and glutamate-pyruvate transaminase (GPT) activities.
Positive_regulation (increase) of glutamate-oxaloacetate transaminase associated with glutamate, methotrexate and death
2) Confidence 0.64 Published 1999 Journal Gen. Pharmacol. Section Abstract Doc Link 10461859 Disease Relevance 0.37 Pain Relevance 0.50
If, additionally, methotrexate is applied, there is an increase in the death rate, as well as in glutamate-oxaloacetate transaminase (GOT) and glutamate-pyruvate transaminase (GPT) activities.
Positive_regulation (increase) of GOT associated with glutamate, methotrexate and death
3) Confidence 0.64 Published 1999 Journal Gen. Pharmacol. Section Abstract Doc Link 10461859 Disease Relevance 0.37 Pain Relevance 0.50
Single oral dosages of the synthetic narcotic analgesic, L-alpha-acetylmethadol (LAAM) increased serum glutamic-pyruvic transaminase (SGPT) levels throughout a two-day observation period and produced a persistent depletion of hepatic and renal glutathione (GSH) levels.
Positive_regulation (increased) of transaminase associated with analgesic
4) Confidence 0.61 Published 1984 Journal Drug Chem Toxicol Section Abstract Doc Link 6723548 Disease Relevance 0.06 Pain Relevance 0.17
In these animals, only minor increases of serum transaminase activities were measured in the presence of AAP, and unlike the exacerbation caused by ethanol in mice on a standard diet, the liver damage was inhibited by 50% by ethanol.
Positive_regulation (increases) of transaminase in liver associated with paracetamol and hepatotoxicity
5) Confidence 0.57 Published 1996 Journal Gen. Pharmacol. Section Abstract Doc Link 8742498 Disease Relevance 0.63 Pain Relevance 0.84
Paracetamol caused hepatotoxicity as judged from elevation of plasma transaminase activities and liver histopathology at a dose of 3.95 mmol/kg.
Positive_regulation (elevation) of transaminase in liver associated with paracetamol and hepatotoxicity
6) Confidence 0.55 Published 1987 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 3603555 Disease Relevance 0.43 Pain Relevance 0.79
DOP (40 mg/kg, i.p.) did not increase the plasma transaminase activity or the lipid peroxides level significantly, whereas AA administration to DOP-treated animals produced earlier maximal elevation of transaminase and lipid peroxide values compared to AA alone.
Neg (not) Positive_regulation (increase) of transaminase in plasma associated with paracetamol
7) Confidence 0.55 Published 1998 Journal Biol. Pharm. Bull. Section Abstract Doc Link 9781842 Disease Relevance 0.31 Pain Relevance 0.93
Hepatosis with reactive hepatitis and non-cholestatic hepatosis with sinusoid ectasia or fatty liver were associated with elevated transaminase levels.
Positive_regulation (elevated) of transaminase in liver associated with fatty liver, pathologic dilatation and hepatitis
8) Confidence 0.54 Published 1978 Journal Dtsch Gesundheitsw Section Abstract Doc Link 668503 Disease Relevance 0.78 Pain Relevance 0.08
PCM induced hepatic damage was manifested by a significant increase in the activities of marker enzymes (alanine transaminase, aspartate transaminase and alkaline phosphatase) in serum and MDA level in liver.
Positive_regulation (increase) of transaminase in liver associated with paracetamol
9) Confidence 0.43 Published 2009 Journal Fundam Clin Pharmacol Section Abstract Doc Link 19656205 Disease Relevance 0.51 Pain Relevance 0.41
PCM induced hepatic damage was manifested by a significant increase in the activities of marker enzymes (alanine transaminase, aspartate transaminase and alkaline phosphatase) in serum and MDA level in liver.
Positive_regulation (increase) of transaminase in liver associated with paracetamol
10) Confidence 0.43 Published 2009 Journal Fundam Clin Pharmacol Section Abstract Doc Link 19656205 Disease Relevance 0.51 Pain Relevance 0.41
The hepatotoxicity of paracetamol in mice measured by an increase of GOT in serum is antagonized by acetylsalicylic acid in dose-dependent manner.
Positive_regulation (increase) of GOT associated with aspirin, paracetamol and hepatotoxicity
11) Confidence 0.40 Published 1984 Journal Arzneimittelforschung Section Abstract Doc Link 6542377 Disease Relevance 0.36 Pain Relevance 1.16
While AAP caused a 117-fold elevation of serum transaminase activities in mice kept on a standard laboratory diet, which was significantly exacerbated by ethanol and inhibited by nicotinic acid amide (NAA), adverse effects were noted in animals fed a diet free of precursors of NAD.
Positive_regulation (elevation) of transaminase associated with paracetamol
12) Confidence 0.38 Published 1996 Journal Gen. Pharmacol. Section Abstract Doc Link 8742498 Disease Relevance 0.60 Pain Relevance 0.78
A 2.1-fold increase of GOT and a 1.9-fold increase of GPT activities (P < 0.001) were observed in mice treated perorally with 500 mg/kg of AAP plus 150 mg/kg of thalidomide (Thal).
Positive_regulation (increase) of GOT associated with paracetamol
13) Confidence 0.37 Published 1995 Journal Gen. Pharmacol. Section Abstract Doc Link 7590113 Disease Relevance 0.25 Pain Relevance 0.67
DOP (40 mg/kg, i.p.) did not increase the plasma transaminase activity or the lipid peroxides level significantly, whereas AA administration to DOP-treated animals produced earlier maximal elevation of transaminase and lipid peroxide values compared to AA alone.
Positive_regulation (elevation) of transaminase in plasma associated with paracetamol
14) Confidence 0.37 Published 1998 Journal Biol. Pharm. Bull. Section Abstract Doc Link 9781842 Disease Relevance 0.29 Pain Relevance 0.91
He developed the picture of acute intoxication with nausea, vomiting, profuse diarrhea, abdominal pain, flushing, temperature, collapse manifestations, hepatomegaly, direct hyperbilirubinemia, elevated transaminase, leukopenia, accelerated ESR.
Positive_regulation (elevated) of transaminase associated with abdominal pain, diarrhoea, leukopenia, shock, vomiting, hepatomegaly, increased venous pressure under development, hyperbilirubinemia and poisoning
15) Confidence 0.36 Published 1985 Journal Vutr Boles Section Abstract Doc Link 4024604 Disease Relevance 1.59 Pain Relevance 0.10
There was also a significant rise in the serum enzyme level of alanine transaminase (P < 0.001) and the area of liver necrosis (P < 0.001), 24 h after paracetamol (400 mg.kg-1) treatment.
Positive_regulation (rise) of transaminase in liver
16) Confidence 0.35 Published 2001 Journal Zhongguo Zhong Yao Za Zhi Section Body Doc Link 12776364 Disease Relevance 0 Pain Relevance 0
Hepatic reduced glutathione (GSH) decreased and plasma glutamic-pyruvic transaminase activity increased in an ACAP dose-dependent manner in weanling mice fed 0.5% methionine.
Positive_regulation (increased) of transaminase in plasma associated with paracetamol
17) Confidence 0.34 Published 1989 Journal J. Nutr. Section Abstract Doc Link 2754511 Disease Relevance 0 Pain Relevance 0.87
(i.v.) 2 h prior to paracetamol, the increase in serum transaminase activity was reduced to 117 +/- 104 units/l and ethane exhalation amounted to 18 +/- 8 nmol kg-1 h-1.
Positive_regulation (increase) of serum transaminase associated with paracetamol
18) Confidence 0.32 Published 1987 Journal Chem. Biol. Interact. Section Abstract Doc Link 3690721 Disease Relevance 0.08 Pain Relevance 0.39
Following intraperitoneal administration of CP (50-300 mg/kg), dose-dependent depletion of hepatic glutathione, increased serum transaminase (SGPT) levels and hepatic necrosis were observed.
Positive_regulation (increased) of serum transaminase associated with necrosis
19) Confidence 0.31 Published 1985 Journal Br J Exp Pathol Section Abstract Doc Link 3882119 Disease Relevance 0.65 Pain Relevance 0.07
Upon treatment with a nonlethal dose (600 mg/kg), WT mice exhibited an increase in serum transaminase levels.
Positive_regulation (increase) of serum transaminase
20) Confidence 0.28 Published 2004 Journal J. Leukoc. Biol. Section Abstract Doc Link 14557383 Disease Relevance 1.21 Pain Relevance 0.68

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