INT320600

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Context Info
Confidence 0.29
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 1.96
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (CEBPZ) DNA binding (CEBPZ)
Anatomy Link Frequency
sympathetic 2
blood 1
sympathetic nervous system 1
TNS3 (Homo sapiens)
CEBPZ (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal-cord stimulation 102 99.40 Very High Very High Very High
Spinal cord 12 92.20 High High
cva 6 90.00 High High
ischemia 6 88.52 High High
medulla 6 81.76 Quite High
tolerance 6 44.64 Quite Low
Pain 30 29.28 Quite Low
painful pain 6 19.88 Low Low
Visceral pain 6 16.88 Low Low
Disease Link Frequency Relevance Heat
Cardiovascular Disease 12 98.54 Very High Very High Very High
Dyspnea 168 95.76 Very High Very High Very High
Cerebrovascular Disease 12 92.56 High High
Cv General 4 Under Development 12 90.00 High High
Increased Venous Pressure Under Development 6 75.28 Quite High
Complex Regional Pain Syndromes 12 29.68 Quite Low
Coronary Heart Disease 6 28.20 Quite Low
Pain 18 27.48 Quite Low
Nociception 6 19.88 Low Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

6 16.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This does not yet prove that TENS does not influence the sympathetic nervous system and CBF, especially because we did notice a tendency towards less decreased blood flow velocities in reaction to hyperventilation when TENS was applied.
TENS Regulation (influence) of CBF in sympathetic nervous system associated with dyspnea
1) Confidence 0.29 Published 2010 Journal Acta Neurochir (Wien) Section Body Doc Link PMC2901492 Disease Relevance 0.38 Pain Relevance 0.08
As for the effect of TENS on CBF, no statistically significant effects were found for the individual TENS frequencies, neither at rest nor in the hyperventilation experiment.
TENS Regulation (effect) of CBF associated with dyspnea
2) Confidence 0.28 Published 2010 Journal Acta Neurochir (Wien) Section Body Doc Link PMC2901492 Disease Relevance 0.34 Pain Relevance 0
We think it is important to further investigate the effect of TENS on CBF in the presence of a disturbed autoregulation, especially since the influence of sympathetic tone is possibly much more significant in these pathological situations.



TENS Regulation (effect) of CBF in sympathetic
3) Confidence 0.28 Published 2010 Journal Acta Neurochir (Wien) Section Body Doc Link PMC2901492 Disease Relevance 0.31 Pain Relevance 0.09
Therefore, in order to find out whether the sympathetic tone is reduced by TENS, the effects of TENS on CBF in hyperventilating subjects is of interest.
TENS Regulation (effects) of CBF in sympathetic
4) Confidence 0.21 Published 2010 Journal Acta Neurochir (Wien) Section Body Doc Link PMC2901492 Disease Relevance 0.35 Pain Relevance 0.20
As cervical TENS is a novel potential therapeutic application in the treatment of CVD, this paper describes the experiments that were performed to assess the effects of TENS on CBF in healthy subjects and to register its potential side effects.


TENS Regulation (effects) of CBF associated with cardiovascular disease
5) Confidence 0.13 Published 2010 Journal Acta Neurochir (Wien) Section Body Doc Link PMC2901492 Disease Relevance 0.34 Pain Relevance 0.09
Taking into account the proven effect of TENS on peripheral blood flow and its (indirect) effect on sympathetic tone, TENS should be able to alter CBF, an analog to SCS.
TENS Regulation (alter) of CBF in blood associated with spinal-cord stimulation
6) Confidence 0.13 Published 2010 Journal Acta Neurochir (Wien) Section Body Doc Link PMC2901492 Disease Relevance 0.24 Pain Relevance 0.28

General Comments

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